Scalp recordings of mid-latency AEP and auditory gating in the Göttingen minipig: a new animal model in information processing research.

S M Arnfred; N M Lind; A Gjedde; A K Hansen

doi:10.1016/j.ijpsycho.2003.11.002

Scalp recordings of mid-latency AEP and auditory gating in the Göttingen minipig: a new animal model in information processing research.

S M Arnfred, N M Lind, A Gjedde, A K Hansen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Udgivelsesdato: 2004-May

Originalsprog	Engelsk
Tidsskrift	International Journal of Psychophysiology
Vol/bind	52
Udgave nummer	3
Sider (fra-til)	267-75
Antal sider	8
ISSN	0167-8760
DOI	https://doi.org/10.1016/j.ijpsycho.2003.11.002
Status	Udgivet - 2004
Udgivet eksternt	Ja

Bibliografisk note

Adgang til dokumentet

10.1016/j.ijpsycho.2003.11.002

Citationsformater

@article{fc8bed00b31411debc73000ea68e967b,

title = "Scalp recordings of mid-latency AEP and auditory gating in the G{\"o}ttingen minipig: a new animal model in information processing research.",

abstract = "Early central information processing, measured in humans by the gating of the middle latency auditory evoked potential (AEP) P50 and the effect of attention on AEP N100, is affected in schizophrenia. Exploring the possibility of using miniature pigs in longitudinal studies of chronic neuropsychiatric disorders, we present a method for recording seven channel surface middle latency AEP in the awake animal. The AEP and the AEP gating measured in a paired stimulus paradigm similar to the P50 gating paradigm used in humans, were recorded in six adult male minipigs in two sessions. The AEP had a stable N40/P60/N120/P200 configuration and in the gating paradigm the difference between stimulus one (S1) and two (S2) P60 and N120 amplitudes were significant. Mean AEP P60 gating ratio (S2/S1) at the posterior central electrode was 0.66 (std 0.29) range 0.21-1.08 and corresponding N120 was 0.60 (std 0.19) range 0.28-0.76. The method presented is feasible for scalp recordings of middle latency evoked potentials in the awake animal, but further studies of interval sensitivity and the effect of arousal manipulation are needed to assess the equivalence of the pig components to those of the human at similar latencies.",

author = "Arnfred, {S M} and Lind, {N M} and A Gjedde and Hansen, {A K}",

year = "2004",

doi = "10.1016/j.ijpsycho.2003.11.002",

language = "English",

volume = "52",

pages = "267--75",

journal = "International Journal of Psychophysiology",

issn = "0167-8760",

publisher = "Elsevier",

number = "3",

}

TY - JOUR

T1 - Scalp recordings of mid-latency AEP and auditory gating in the Göttingen minipig: a new animal model in information processing research.

AU - Arnfred, S M

AU - Lind, N M

AU - Gjedde, A

AU - Hansen, A K

PY - 2004

Y1 - 2004

N2 - Early central information processing, measured in humans by the gating of the middle latency auditory evoked potential (AEP) P50 and the effect of attention on AEP N100, is affected in schizophrenia. Exploring the possibility of using miniature pigs in longitudinal studies of chronic neuropsychiatric disorders, we present a method for recording seven channel surface middle latency AEP in the awake animal. The AEP and the AEP gating measured in a paired stimulus paradigm similar to the P50 gating paradigm used in humans, were recorded in six adult male minipigs in two sessions. The AEP had a stable N40/P60/N120/P200 configuration and in the gating paradigm the difference between stimulus one (S1) and two (S2) P60 and N120 amplitudes were significant. Mean AEP P60 gating ratio (S2/S1) at the posterior central electrode was 0.66 (std 0.29) range 0.21-1.08 and corresponding N120 was 0.60 (std 0.19) range 0.28-0.76. The method presented is feasible for scalp recordings of middle latency evoked potentials in the awake animal, but further studies of interval sensitivity and the effect of arousal manipulation are needed to assess the equivalence of the pig components to those of the human at similar latencies.

AB - Early central information processing, measured in humans by the gating of the middle latency auditory evoked potential (AEP) P50 and the effect of attention on AEP N100, is affected in schizophrenia. Exploring the possibility of using miniature pigs in longitudinal studies of chronic neuropsychiatric disorders, we present a method for recording seven channel surface middle latency AEP in the awake animal. The AEP and the AEP gating measured in a paired stimulus paradigm similar to the P50 gating paradigm used in humans, were recorded in six adult male minipigs in two sessions. The AEP had a stable N40/P60/N120/P200 configuration and in the gating paradigm the difference between stimulus one (S1) and two (S2) P60 and N120 amplitudes were significant. Mean AEP P60 gating ratio (S2/S1) at the posterior central electrode was 0.66 (std 0.29) range 0.21-1.08 and corresponding N120 was 0.60 (std 0.19) range 0.28-0.76. The method presented is feasible for scalp recordings of middle latency evoked potentials in the awake animal, but further studies of interval sensitivity and the effect of arousal manipulation are needed to assess the equivalence of the pig components to those of the human at similar latencies.

U2 - 10.1016/j.ijpsycho.2003.11.002

DO - 10.1016/j.ijpsycho.2003.11.002

M3 - Journal article

C2 - 15094249

VL - 52

SP - 267

EP - 275

JO - International Journal of Psychophysiology

JF - International Journal of Psychophysiology

SN - 0167-8760

IS - 3

ER -