Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Nuclear Cardiology |
| Vol/bind | 16 |
| Udgave nummer | 5 |
| Sider (fra-til) | 784-91 |
| Antal sider | 7 |
| ISSN | 1071-3581 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Angioplasty, Transluminal, Percutaneous Coronary; Combined Modality Therapy; Denmark; Embolization, Therapeutic; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Risk Assessment; Risk Factors; Survival Analysis; Survival RateAdgang til dokumentet
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I: Journal of Nuclear Cardiology, Bind 16, Nr. 5, 2009, s. 784-91.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Scintigraphic evaluation of routine filterwire distal protection in percutaneous coronary intervention for acute ST-segment elevation myocardial infarction: a randomized controlled trial
AU - Kaltoft, Anne
AU - Nielsen, Søren Steen
AU - Terkelsen, Christian Juhl
AU - Bøttcher, Morten
AU - Lassen, Jens Flensted
AU - Krusell, Lars Romer
AU - Kristensen, Steen Dalby
AU - Ravkilde, Jan
AU - Kelbaek, Henning
AU - Bøtker, Hans Erik
AU - Christiansen, Evald Høj
AU - Rehling, Michael
AU - Thuesen, Leif
N1 - Keywords: Angioplasty, Transluminal, Percutaneous Coronary; Combined Modality Therapy; Denmark; Embolization, Therapeutic; Female; Humans; Incidence; Male; Middle Aged; Myocardial Infarction; Risk Assessment; Risk Factors; Survival Analysis; Survival Rate
PY - 2009
Y1 - 2009
N2 - AIM: Distal embolization during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) may result in reduced myocardial perfusion, infarct extension and impaired prognosis. In a prospective randomized trial, we assessed the effect of routine filterwire distal protection on scintigraphic estimated infarct size. METHODS AND RESULTS: The effect of routine filterwire distal protection was evaluated in 344 patients with STEMI <12 hours undergoing primary PCI. Patients were randomized to distal protection with a filterwire or standard PCI. The primary endpoint was myocardial infarct size measured by Sestamibi SPECT after 30 days (%). Secondary endpoints included myocardial salvage, ST-segment resolution (STR), myocardial biomarker release and major adverse cardiac and cerebral events. Baseline characteristics including area at risk (estimated by Sestamibi SPECT) were similar. Final infarct size was not statistically different in the distal protection and the control groups (median [IQR], 6% [1-19] and 5% [1-14], P = .23). Also, secondary endpoints were similar in the two treatment groups. CONCLUSION: Distal protection with a filterwire performed as routine therapy in primary PCI for STEMI did not reduce myocardial infarct size. The study does not support routine use of distal protection in primary PCI.
AB - AIM: Distal embolization during primary percutaneous coronary intervention (PCI) for ST-elevation myocardial infarction (STEMI) may result in reduced myocardial perfusion, infarct extension and impaired prognosis. In a prospective randomized trial, we assessed the effect of routine filterwire distal protection on scintigraphic estimated infarct size. METHODS AND RESULTS: The effect of routine filterwire distal protection was evaluated in 344 patients with STEMI <12 hours undergoing primary PCI. Patients were randomized to distal protection with a filterwire or standard PCI. The primary endpoint was myocardial infarct size measured by Sestamibi SPECT after 30 days (%). Secondary endpoints included myocardial salvage, ST-segment resolution (STR), myocardial biomarker release and major adverse cardiac and cerebral events. Baseline characteristics including area at risk (estimated by Sestamibi SPECT) were similar. Final infarct size was not statistically different in the distal protection and the control groups (median [IQR], 6% [1-19] and 5% [1-14], P = .23). Also, secondary endpoints were similar in the two treatment groups. CONCLUSION: Distal protection with a filterwire performed as routine therapy in primary PCI for STEMI did not reduce myocardial infarct size. The study does not support routine use of distal protection in primary PCI.
U2 - 10.1007/s12350-009-9105-x
DO - 10.1007/s12350-009-9105-x
M3 - Journal article
C2 - 19521742
SN - 1071-3581
VL - 16
SP - 784
EP - 791
JO - Journal of Nuclear Cardiology
JF - Journal of Nuclear Cardiology
IS - 5
ER -