Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Fertility and Sterility |
| Vol/bind | 118 |
| Udgave nummer | 4 |
| Sider (fra-til) | 671-678 |
| Antal sider | 8 |
| ISSN | 0015-0282 |
| DOI | |
| Status | Udgivet - 2022 |
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Semen quality and reproductive hormones in sons of subfertile couples : a cohort study. / Arendt, Linn H.; Gaml-Sorensen, Anne; Ernst, Andreas; Brix, Nis; Toft, Gunnar; Tottenborg, Sandra S.; Hougaard, Karin S.; Bonde, Jens Peter E.; Ramlau-Hansen, Cecilia H.
I: Fertility and Sterility, Bind 118, Nr. 4, 2022, s. 671-678.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Semen quality and reproductive hormones in sons of subfertile couples
T2 - a cohort study
AU - Arendt, Linn H.
AU - Gaml-Sorensen, Anne
AU - Ernst, Andreas
AU - Brix, Nis
AU - Toft, Gunnar
AU - Tottenborg, Sandra S.
AU - Hougaard, Karin S.
AU - Bonde, Jens Peter E.
AU - Ramlau-Hansen, Cecilia H.
PY - 2022
Y1 - 2022
N2 - Objective: To study the associations between parental subfecundity, assessed by time to pregnancy and use of medically-assisted reproduction, and reproductive health of young men.Design: Cohort study.Setting: Denmark.Patient(s): A total of 1,058 men in the Fetal Programming of Semen quality cohort, a subcohort of the Danish National Birth Cohort. Intervention(s): From 2017-2019, men were recruited and provided semen and blood samples. Information on parental time to pregnancy and use of medically-assisted reproduction (including type of treatment) as well as demographic, health, and lifestyle factors were available. We estimated the crude and adjusted relative percentage differences with 95% confidence intervals (CIs) in the outcomes according to time to pregnancy and use of medically-assisted reproduction, using multiple adjusted negative binomial regression analysis.Main Outcome Measure(s): Semen characteristics (semen volume, sperm concentration, total sperm count, sperm motility, and morphology), testicular volume, and reproductive hormone levels (follicle stimulating hormone, luteinizing hormone, testosterone, estradiol, sex hormone-binding globulin, and free androgen index). Result(s): Overall, semen quality and levels of reproductive hormones were not lower among sons of subfecund parents reporting a time to pregnancy >6 months or use of intrauterine insemination. Sons conceived after in vitro fertilization or intracytoplasmic sperm injection, had a higher semen concentration (29%; 95% CI, -7%-79%) and a higher percentage of sperm with normal morphology (20%; 95% CI, -8%-56%), but with 95% CI overlapping the null. Moreover, these sons had slightly higher estradiol levels (30%; 95% CI, 7%-57%). The absolute differences seen were small, and the clinical significance of these differences are unknown.Conclusion(s): We found no major difference in semen quality or reproductive hormones in sons conceived by subfertile couples or with the use of medically-assisted reproduction. (Fertil Sterile 2022;118:671-78. (c) 2022 by American Society for Reproductive Medicine.) El resumen esta disponible en Espanol al final del articulo.
AB - Objective: To study the associations between parental subfecundity, assessed by time to pregnancy and use of medically-assisted reproduction, and reproductive health of young men.Design: Cohort study.Setting: Denmark.Patient(s): A total of 1,058 men in the Fetal Programming of Semen quality cohort, a subcohort of the Danish National Birth Cohort. Intervention(s): From 2017-2019, men were recruited and provided semen and blood samples. Information on parental time to pregnancy and use of medically-assisted reproduction (including type of treatment) as well as demographic, health, and lifestyle factors were available. We estimated the crude and adjusted relative percentage differences with 95% confidence intervals (CIs) in the outcomes according to time to pregnancy and use of medically-assisted reproduction, using multiple adjusted negative binomial regression analysis.Main Outcome Measure(s): Semen characteristics (semen volume, sperm concentration, total sperm count, sperm motility, and morphology), testicular volume, and reproductive hormone levels (follicle stimulating hormone, luteinizing hormone, testosterone, estradiol, sex hormone-binding globulin, and free androgen index). Result(s): Overall, semen quality and levels of reproductive hormones were not lower among sons of subfecund parents reporting a time to pregnancy >6 months or use of intrauterine insemination. Sons conceived after in vitro fertilization or intracytoplasmic sperm injection, had a higher semen concentration (29%; 95% CI, -7%-79%) and a higher percentage of sperm with normal morphology (20%; 95% CI, -8%-56%), but with 95% CI overlapping the null. Moreover, these sons had slightly higher estradiol levels (30%; 95% CI, 7%-57%). The absolute differences seen were small, and the clinical significance of these differences are unknown.Conclusion(s): We found no major difference in semen quality or reproductive hormones in sons conceived by subfertile couples or with the use of medically-assisted reproduction. (Fertil Sterile 2022;118:671-78. (c) 2022 by American Society for Reproductive Medicine.) El resumen esta disponible en Espanol al final del articulo.
KW - Cohort study
KW - fecundity
KW - fertility
KW - infertility
KW - reproduction
KW - reproductive hormones
KW - risk factors
KW - semen quality
KW - subfecundity
KW - ASSISTED REPRODUCTION
KW - INHIBIN B
KW - EPIDEMIOLOGY
KW - INFERTILITY
KW - TECHNOLOGY
KW - HEALTH
KW - MEN
U2 - 10.1016/j.fertnstert.2022.06.035
DO - 10.1016/j.fertnstert.2022.06.035
M3 - Journal article
C2 - 35985861
VL - 118
SP - 671
EP - 678
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
SN - 1546-2501
IS - 4
ER -