Senescence of skeletal stem cells and their contribution to age-related bone loss

Eva M. Wölfel; Paula Fernandez-Guerra; Mikkel Ørnfeldt Nørgård; Shakespeare Jeromdesella; Pernille Kirkegaard Kjær; Anna Sofie Elkjær; Moustapha Kassem; Florence Figeac

doi:10.1016/j.mad.2024.111976

Senescence of skeletal stem cells and their contribution to age-related bone loss

Eva M. Wölfel^*, Paula Fernandez-Guerra, Mikkel Ørnfeldt Nørgård, Shakespeare Jeromdesella, Pernille Kirkegaard Kjær, Anna Sofie Elkjær, Moustapha Kassem, Florence Figeac

^*Corresponding author af dette arbejde

Morphogenesis and Differentiation Program

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Abstract

Human aging is linked to bone loss, resulting in bone fragility and an increased risk of fractures. This is primarily due to an age-related decline in the function of bone-forming osteoblastic cells and accelerated cellular senescence within the bone microenvironment. Here, we provide a detailed discussion of the hypothesis that age-related defective bone formation is caused by senescence of skeletal stem cells, as they are the main source of bone forming osteoblastic cells and influence the composition of bone microenvironment. Furthermore, this review discusses potential strategies to target cellular senescence as an emerging approach to treat age-related bone loss.

Originalsprog	Engelsk
Artikelnummer	111976
Tidsskrift	Mechanisms of Ageing and Development
Vol/bind	221
Antal sider	8
ISSN	0047-6374
DOI	https://doi.org/10.1016/j.mad.2024.111976
Status	Udgivet - 2024

Bibliografisk note

Funding Information:
This work was supported by Novo Nordisk Fonden (NNF21OC0067839 and NFNF20OC0065814).

Publisher Copyright:
© 2024 The Authors

Adgang til dokumentet

10.1016/j.mad.2024.111976Licens: CC BY

FulltextForlagets udgivne version, 947 KBLicens: CC BY

Citationsformater

Senescence of skeletal stem cells and their contribution to age-related bone loss. / Wölfel, Eva M.; Fernandez-Guerra, Paula; Nørgård, Mikkel Ørnfeldt; Jeromdesella, Shakespeare; Kjær, Pernille Kirkegaard; Elkjær, Anna Sofie; Kassem, Moustapha; Figeac, Florence.

I: Mechanisms of Ageing and Development, Bind 221, 111976, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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AU - Fernandez-Guerra, Paula

AU - Nørgård, Mikkel Ørnfeldt

AU - Jeromdesella, Shakespeare

AU - Kjær, Pernille Kirkegaard

AU - Elkjær, Anna Sofie

AU - Kassem, Moustapha

AU - Figeac, Florence

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KW - Age-related bone disease

KW - Cellular senescence

KW - Marrow stromal stem cells

KW - Skeletal stem cells

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