Sensing of RNA viruses: a review of innate immune receptors involved in recognizing RNA virus invasion

Søren Jensen, Allan Randrup Thomsen

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    475 Citationer (Scopus)

    Abstract

    Our knowledge regarding the contribution of the innate immune system in recognizing and subsequently initiating a host response to an invasion of RNA virus has been rapidly growing over the last decade. Descriptions of the receptors involved and the molecular mechanisms they employ to sense viral pathogen-associated molecular patterns have emerged in great detail. This review presents an overview of our current knowledge regarding the receptors used to detect RNA virus invasion, the molecular structures these receptors sense, and the involved downstream signaling pathways.
    OriginalsprogEngelsk
    TidsskriftJournal of Virology
    Vol/bind86
    Udgave nummer6
    Sider (fra-til)2900-2910
    Antal sider11
    ISSN0022-538X
    DOI
    StatusUdgivet - mar. 2012

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