Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | J A I D S |
| Vol/bind | 55 |
| Udgave nummer | 2 |
| Sider (fra-til) | 262-70 |
| Antal sider | 9 |
| ISSN | 1525-4135 |
| DOI | |
| Status | Udgivet - 1 okt. 2010 |
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Serious fatal and nonfatal non-AIDS-defining illnesses in Europe. / Mocroft, Amanda; Reiss, Peter; Gasiorowski, Jacek; Ledergerber, Bruno; Kowalska, Justyna; Chiesi, Antonio; Gatell, Jose; Rakhmanova, Aza; Johnson, Margaret; Kirk, Ole; Eurosida Study Group ; Lundgren, Jens.
I: J A I D S, Bind 55, Nr. 2, 01.10.2010, s. 262-70.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Serious fatal and nonfatal non-AIDS-defining illnesses in Europe
AU - Mocroft, Amanda
AU - Reiss, Peter
AU - Gasiorowski, Jacek
AU - Ledergerber, Bruno
AU - Kowalska, Justyna
AU - Chiesi, Antonio
AU - Gatell, Jose
AU - Rakhmanova, Aza
AU - Johnson, Margaret
AU - Kirk, Ole
AU - Eurosida Study Group
AU - Lundgren, Jens
PY - 2010/10/1
Y1 - 2010/10/1
N2 - BACKGROUND: Little is known about the incidence and risk factors for serious non-AIDS-defining events. METHODS: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. RESULTS: Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05). CONCLUSIONS: Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need.
AB - BACKGROUND: Little is known about the incidence and risk factors for serious non-AIDS-defining events. METHODS: The incidence of non-AIDS events (malignancies, end-stage renal disease, liver failure, pancreatitis, cardiovascular disease), and AIDS after January 1, 2001, was calculated; Poisson regression was used to investigate factors associated with non-AIDS and AIDS. RESULTS: Among 12,844 patients, 1058 were diagnosed with a non-AIDS event [incidence 1.77 per 100 person-years of follow-up; 95% confidence interval (CI): 1.66 to 1.87]; 462 patients (43.7%) died. The incidence of AIDS (1025 diagnoses; 339 deaths, 33.1%) was 1.72 per 100 person-years of follow-up (1.61 to 1.83). After adjustment, older age [incidence rate ratio (IRR): 1.71 per 10 years older, 95% CI: 1.60 to 1.83], diabetes (IRR: 1.49, 95% CI: 1.22 to 1.82) and hypertension (IRR: 1.63, 95% CI: 1.43 to 1.87) were associated with non-AIDS events. Compared with patients without an event, there was a 4-fold increased risk of death after an AIDS event (relative hazard: 4.14; 95% CI 3.47 to 4.94) and almost a 7-fold increased risk of death after a non-AIDS event (relative hazard: 6.72; 95% CI: 5.61 to 8.05). CONCLUSIONS: Non-AIDS events were common in the combination antiretroviral therapy era and associated with considerably mortality. Evidence on the impact of modifying immunodeficiency and lifestyle-related factors on the risk of non-AIDS events in HIV-infected persons is an important but unmet research need.
U2 - 10.1097/QAI.0b013e3181e9be6b
DO - 10.1097/QAI.0b013e3181e9be6b
M3 - Journal article
C2 - 20700060
VL - 55
SP - 262
EP - 270
JO - J A I D S
JF - J A I D S
SN - 1525-4135
IS - 2
ER -