Sex of prior children and risk of stillbirth in subsequent pregnancies

Henriette Svarre Nielsen; Laust Hvas Mortensen; Ulrikka Nygaard; Ole Schnor; Ole Bjarne Christiansen; Anne-Marie Nybo Andersen

doi:10.1097/EDE.0b013e3181c04dcf

Sex of prior children and risk of stillbirth in subsequent pregnancies

Henriette Svarre Nielsen, Laust Hvas Mortensen, Ulrikka Nygaard, Ole Schnor, Ole Bjarne Christiansen, Anne-Marie Nybo Andersen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

14 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-Jan

Originalsprog	Engelsk
Tidsskrift	Epidemiology
Vol/bind	21
Udgave nummer	1
Sider (fra-til)	114-7
Antal sider	3
ISSN	1044-3983
DOI	https://doi.org/10.1097/EDE.0b013e3181c04dcf
Status	Udgivet - 2010

Adgang til dokumentet

10.1097/EDE.0b013e3181c04dcf

Citationsformater

@article{2d047f109f0011df928f000ea68e967b,

title = "Sex of prior children and risk of stillbirth in subsequent pregnancies",

abstract = "BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.",

author = "Nielsen, {Henriette Svarre} and Mortensen, {Laust Hvas} and Ulrikka Nygaard and Ole Schnor and Christiansen, {Ole Bjarne} and Andersen, {Anne-Marie Nybo}",

year = "2010",

doi = "10.1097/EDE.0b013e3181c04dcf",

language = "English",

volume = "21",

pages = "114--7",

journal = "Epidemiology",

issn = "1044-3983",

publisher = "Lippincott Williams & Wilkins",

number = "1",

}

TY - JOUR

T1 - Sex of prior children and risk of stillbirth in subsequent pregnancies

AU - Nielsen, Henriette Svarre

AU - Mortensen, Laust Hvas

AU - Nygaard, Ulrikka

AU - Schnor, Ole

AU - Christiansen, Ole Bjarne

AU - Andersen, Anne-Marie Nybo

PY - 2010

Y1 - 2010

N2 - BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.

AB - BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.

U2 - 10.1097/EDE.0b013e3181c04dcf

DO - 10.1097/EDE.0b013e3181c04dcf

M3 - Journal article

C2 - 19901840

VL - 21

SP - 114

EP - 117

JO - Epidemiology

JF - Epidemiology

SN - 1044-3983

IS - 1

ER -