Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Epidemiology |
Vol/bind | 21 |
Udgave nummer | 1 |
Sider (fra-til) | 114-7 |
Antal sider | 3 |
ISSN | 1044-3983 |
DOI | |
Status | Udgivet - 2010 |
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Sex of prior children and risk of stillbirth in subsequent pregnancies. / Nielsen, Henriette Svarre; Mortensen, Laust Hvas; Nygaard, Ulrikka; Schnor, Ole; Christiansen, Ole Bjarne; Andersen, Anne-Marie Nybo.
I: Epidemiology, Bind 21, Nr. 1, 2010, s. 114-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Sex of prior children and risk of stillbirth in subsequent pregnancies
AU - Nielsen, Henriette Svarre
AU - Mortensen, Laust Hvas
AU - Nygaard, Ulrikka
AU - Schnor, Ole
AU - Christiansen, Ole Bjarne
AU - Andersen, Anne-Marie Nybo
PY - 2010
Y1 - 2010
N2 - BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.
AB - BACKGROUND: Delivery of a boy has been reported to increase a woman's risk of recurrent miscarriage in subsequent pregnancies. We explored whether delivery of boys similarly increases the risk of a subsequent stillbirth. METHODS: We identified all Danish women delivering their first child (singleton) between 1980 and 1998 (n = 499,731) using the Danish Birth Registry. These women had subsequent singleton births through 2004 (n = 558,314). We assessed the risk of stillbirth conditional on sex of prior children. RESULTS: The risk of stillbirth was increased by 12% after deliver of boys compared with girls (relative risk = 1.12 [95% confidence interval = 1.02-1.23]). This association did not appear to be explained by maternal confounders. CONCLUSION: Stillbirth risk appears to be slightly higher among the pregnancies of women who have previously delivered a boy. One possible mechanism is maternal immune response to male-specific minor histocompatibility antigens initiated during pregnancies with boys.
U2 - 10.1097/EDE.0b013e3181c04dcf
DO - 10.1097/EDE.0b013e3181c04dcf
M3 - Journal article
C2 - 19901840
VL - 21
SP - 114
EP - 117
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 1
ER -