TY - JOUR
T1 - Shift work and incidence of dementia
T2 - A Danish Nurse Cohort study
AU - Jørgensen, Jeanette Therming
AU - Hansen, Johnni
AU - Westendorp, Rudi G.J.
AU - Nabe-Nielsen, Kirsten
AU - Stayner, Leslie Thomas
AU - Simonsen, Mette Kildevæld
AU - Andersen, Zorana Jovanovic
PY - 2020
Y1 - 2020
N2 - Introduction: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. Methods: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. Results: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). Discussion: Persistent night shift work may increase the risk of dementia.
AB - Introduction: A few studies suggest that working night and rotating shifts increase the risk of dementia. We examined the association between shift work and the incidence of dementia in a cohort of female Danish nurses. Methods: We linked Danish Nurse Cohort participants, who reported work schedules (day, evening, night, rotating shifts) in 1993 and/or 1999 and their duration in 2009, to Danish registers to obtain information on dementia hospitalizations and prescription medication until November 2018. Results: Among 6048 nurses who reported work schedules in 1993 and 1999, nurses working night shifts ≥6 years had higher dementia incidence (hazard ratio: 2.43, 95% confidence interval: 1.39 to 4.23) than those working day shifts ≥6 years. Among 8059 nurses who reported shift work duration, nurses working night shifts ≥6 years had higher dementia incidence than those working night shifts <1 year (1.47, 1.06 to 2.06). Discussion: Persistent night shift work may increase the risk of dementia.
KW - Alzheimer's disease and dementia
KW - cohort study
KW - Danish Nurse Cohort
KW - Denmark
KW - neurodegenerative disease
KW - night shift work
KW - shift work
KW - working time
U2 - 10.1002/alz.12126
DO - 10.1002/alz.12126
M3 - Journal article
C2 - 32652788
AN - SCOPUS:85087713262
SN - 1552-5260
VL - 16
SP - 1268
EP - 1279
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 9
ER -