@article{fe581540359c11df8ed1000ea68e967b,
title = "Short- and long-term effects of endurance training in patients with mitochondrial myopathy",
abstract = "BACKGROUND AND PURPOSE: It is unknown whether prolonged training is a safe treatment to alleviate exercise intolerance in patients with mitochondrial DNA (mtDNA) mutations. METHODS: The effect of 3 and 12 months training and 3-12 months deconditioning was studied in four patients carrying different mtDNA mutations. RESULTS: Three-month moderate-intensity training increased oxidative capacity by 23%, which was sustained after 6-12 months of low-intensity training. Training and deconditioning did not induce adverse effects on clinical symptoms, muscle morphology and mtDNA mutation load in muscle. CONCLUSION: Long-term training effectively improves exercise capacity in patients with mitochondrial myopathy, and appears to be safe.",
author = "Jeppesen, {T D} and M Dun{\o} and M Schwartz and T Krag and J Rafiq and F Wibrand and J Vissing",
note = "Keywords: Exercise Therapy; Exercise Tolerance; Humans; Mitochondrial Myopathies; Muscle, Skeletal; Time",
year = "2009",
doi = "10.1111/j.1468-1331.2009.02660.x",
language = "English",
volume = "16",
pages = "1336--9",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell",
number = "12",
}