TY - JOUR
T1 - Shorter duration of breastfeeding at elevated exposures to perfluoroalkyl substances
AU - Timmermann, Clara Amalie Gade
AU - Budtz-Jørgensen, Esben
AU - Petersen, Maria Skaalum
AU - Weihe, Pál
AU - Steuerwald, Ulrike
AU - Nielsen, Flemming
AU - Jensen, Tina Kold
AU - Grandjean, Philippe
PY - 2017/3
Y1 - 2017/3
N2 - The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.
AB - The aim of this study was to determine whether maternal exposure to persistent perfluoroalkyl substances (PFASs) affect the capability to breastfeed.In two Faroese birth cohorts (N = 1130), concentrations of five PFASs were measured in maternal serum during pregnancy or two weeks after term. Duration of breastfeeding was assessed by questionnaire and clinical interview. In adjusted linear regression models, a doubling of maternal serum PFASs was associated with a reduction in duration of both total and exclusive breastfeeding, most pronounced for perfluorooctane sulfonic acid (PFOS) where a doubling was associated with a reduction in total breastfeeding of 1.4 (95% CI: 0.6; 2.1) months and perfluorooctanoic acid (PFOA) where a doubling was associated with a reduction in exclusive breastfeeding of 0.5 (0.3; 0.7) months. The associations were evident among both primiparous and multiparous women, and thus cannot be explained by confounding from previous breastfeeding.
KW - Breast milk
KW - Breastfeeding
KW - Endocrine disruption
KW - Lactation
KW - Maternal health
KW - Perfluoroalkyl substances
UR - http://www.scopus.com/inward/record.url?scp=84979573900&partnerID=8YFLogxK
U2 - 10.1016/j.reprotox.2016.07.010
DO - 10.1016/j.reprotox.2016.07.010
M3 - Journal article
C2 - 27421579
AN - SCOPUS:84979573900
VL - 68
SP - 164
EP - 170
JO - Reproductive Toxicology
JF - Reproductive Toxicology
SN - 0890-6238
ER -