Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.

Vania Rosas-Magallanes; Gustavo Stadthagen-Gomez; Jean Rauzier; Luis B Barreiro; Ludovic Tailleux; Frédéric Boudou; Ruth Griffin; Jérome Nigou; Mary Jackson; Brigitte Gicquel; Olivier Neyrolles

doi:10.1128/IAI.00058-06

Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.

Vania Rosas-Magallanes, Gustavo Stadthagen-Gomez, Jean Rauzier, Luis B Barreiro, Ludovic Tailleux, Frédéric Boudou, Ruth Griffin, Jérome Nigou, Mary Jackson, Brigitte Gicquel, Olivier Neyrolles

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

64 Citationer (Scopus)

Abstract

Udgivelsesdato: 2007-Jan

Originalsprog	Engelsk
Tidsskrift	Infection and Immunity
Vol/bind	75
Udgave nummer	1
Sider (fra-til)	504-7
Antal sider	3
ISSN	0019-9567
DOI	https://doi.org/10.1128/IAI.00058-06
Status	Udgivet - 2006
Udgivet eksternt	Ja

Bibliografisk note

Keywords: Animals; Bacterial Proteins; DNA Transposable Elements; Female; Genes, Bacterial; Humans; Macrophages; Mice; Mice, Inbred C57BL; Mutagenesis; Mycobacterium tuberculosis

Adgang til dokumentet

10.1128/IAI.00058-06

Citationsformater

Rosas-Magallanes, V., Stadthagen-Gomez, G., Rauzier, J., Barreiro, L. B., Tailleux, L., Boudou, F., Griffin, R., Nigou, J., Jackson, M., Gicquel, B., & Neyrolles, O. (2006). Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages. Infection and Immunity, 75(1), 504-7. https://doi.org/10.1128/IAI.00058-06

Rosas-Magallanes, V, Stadthagen-Gomez, G, Rauzier, J, Barreiro, LB, Tailleux, L, Boudou, F, Griffin, R, Nigou, J, Jackson, M, Gicquel, B & Neyrolles, O 2006, 'Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.', Infection and Immunity, bind 75, nr. 1, s. 504-7. https://doi.org/10.1128/IAI.00058-06

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title = "Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.",

abstract = "Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.",

author = "Vania Rosas-Magallanes and Gustavo Stadthagen-Gomez and Jean Rauzier and Barreiro, {Luis B} and Ludovic Tailleux and Fr{\'e}d{\'e}ric Boudou and Ruth Griffin and J{\'e}rome Nigou and Mary Jackson and Brigitte Gicquel and Olivier Neyrolles",

note = "Keywords: Animals; Bacterial Proteins; DNA Transposable Elements; Female; Genes, Bacterial; Humans; Macrophages; Mice; Mice, Inbred C57BL; Mutagenesis; Mycobacterium tuberculosis",

year = "2006",

doi = "10.1128/IAI.00058-06",

language = "English",

volume = "75",

pages = "504--7",

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T1 - Signature-tagged transposon mutagenesis identifies novel Mycobacterium tuberculosis genes involved in the parasitism of human macrophages.

AU - Rosas-Magallanes, Vania

AU - Stadthagen-Gomez, Gustavo

AU - Rauzier, Jean

AU - Barreiro, Luis B

AU - Tailleux, Ludovic

AU - Boudou, Frédéric

AU - Griffin, Ruth

AU - Nigou, Jérome

AU - Jackson, Mary

AU - Gicquel, Brigitte

AU - Neyrolles, Olivier

N1 - Keywords: Animals; Bacterial Proteins; DNA Transposable Elements; Female; Genes, Bacterial; Humans; Macrophages; Mice; Mice, Inbred C57BL; Mutagenesis; Mycobacterium tuberculosis

PY - 2006

Y1 - 2006

N2 - Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

AB - Using signature-tagged transposon mutagenesis, we isolated 23 Mycobacterium tuberculosis mutants, corresponding to 21 genes or genetic regions, attenuated in their ability to parasitize human macrophages. Mutants disrupted in the ABC transporter-encoding genes Rv0986 and Rv0987 were further characterized as being impaired in their ability to bind to host cells.

U2 - 10.1128/IAI.00058-06

DO - 10.1128/IAI.00058-06

M3 - Journal article

C2 - 17030567

SN - 0019-9567

VL - 75

SP - 504

EP - 507

JO - Infection and Immunity

JF - Infection and Immunity

IS - 1

ER -