Significance of birth in the maintenance of quiescent neural stem cells

Koya Kawase; Yasuhisa Nakamura; Laura Wolbeck; Shoko Takemura; Kei Zaitsu; Takehiro Ando; Hideo Jinnou; Masato Sawada; Chikako Nakajima; Rasmus Rydbirk; Sakura Gokenya; Akira Ito; Hitomi Fujiyama; Akari Saito; Akira Iguchi; Panagiotis Kratimenos; Nobuyuki Ishibashi; Vittorio Gallo; Osuke Iwata; Shinji Saitoh; Konstantin Khodosevich; Kazunobu Sawamoto

doi:10.1126/sciadv.adn6377

Significance of birth in the maintenance of quiescent neural stem cells

Koya Kawase, Yasuhisa Nakamura, Laura Wolbeck, Shoko Takemura, Kei Zaitsu, Takehiro Ando, Hideo Jinnou, Masato Sawada, Chikako Nakajima, Rasmus Rydbirk, Sakura Gokenya, Akira Ito, Hitomi Fujiyama, Akari Saito, Akira Iguchi, Panagiotis Kratimenos, Nobuyuki Ishibashi, Vittorio Gallo, Osuke Iwata, Shinji SaitohKonstantin Khodosevich, Kazunobu Sawamoto^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

2 Citationer (Scopus)

11 Downloads (Pure)

Abstract

Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs. Preterm birth impairs this cellular process, leading to transient hyperactivation of RG. Consequently, in the postnatal brain, the NSC pool is depleted and neurogenesis is decreased. We also found that the maintenance of quiescent RG after preterm birth improves postnatal neurogenesis. This study demonstrates the significance of birth in the maintenance of quiescent NSCs.

Originalsprog	Engelsk
Artikelnummer	eadn6377
Tidsskrift	Science Advances
Vol/bind	11
Udgave nummer	4
Antal sider	17
ISSN	2375-2548
DOI	https://doi.org/10.1126/sciadv.adn6377
Status	Udgivet - 2025

Bibliografisk note

Publisher Copyright:
Copyright © 2025 The Authors.

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10.1126/sciadv.adn6377Licens: CC BY-NC

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Citationsformater

Kawase, K., Nakamura, Y., Wolbeck, L., Takemura, S., Zaitsu, K., Ando, T., Jinnou, H., Sawada, M., Nakajima, C., Rydbirk, R., Gokenya, S., Ito, A., Fujiyama, H., Saito, A., Iguchi, A., Kratimenos, P., Ishibashi, N., Gallo, V., Iwata, O., ... Sawamoto, K. (2025). Significance of birth in the maintenance of quiescent neural stem cells. Science Advances, 11(4), Artikel eadn6377. https://doi.org/10.1126/sciadv.adn6377

Kawase, K, Nakamura, Y, Wolbeck, L, Takemura, S, Zaitsu, K, Ando, T, Jinnou, H, Sawada, M, Nakajima, C, Rydbirk, R, Gokenya, S, Ito, A, Fujiyama, H, Saito, A, Iguchi, A, Kratimenos, P, Ishibashi, N, Gallo, V, Iwata, O, Saitoh, S, Khodosevich, K & Sawamoto, K 2025, 'Significance of birth in the maintenance of quiescent neural stem cells', Science Advances, bind 11, nr. 4, eadn6377. https://doi.org/10.1126/sciadv.adn6377

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title = "Significance of birth in the maintenance of quiescent neural stem cells",

abstract = "Birth is one of the most important life events for animals. However, its significance in the developmental process is not fully understood. Here, we found that birth-induced alteration of glutamine metabolism in radial glia (RG), the embryonic neural stem cells (NSCs), is required for the acquisition of quiescence and long-term maintenance of postnatal NSCs. Preterm birth impairs this cellular process, leading to transient hyperactivation of RG. Consequently, in the postnatal brain, the NSC pool is depleted and neurogenesis is decreased. We also found that the maintenance of quiescent RG after preterm birth improves postnatal neurogenesis. This study demonstrates the significance of birth in the maintenance of quiescent NSCs. ",

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AU - Kawase, Koya

AU - Nakamura, Yasuhisa

AU - Wolbeck, Laura

AU - Takemura, Shoko

AU - Zaitsu, Kei

AU - Ando, Takehiro

AU - Jinnou, Hideo

AU - Sawada, Masato

AU - Nakajima, Chikako

AU - Rydbirk, Rasmus

AU - Gokenya, Sakura

AU - Ito, Akira

AU - Fujiyama, Hitomi

AU - Saito, Akari

AU - Iguchi, Akira

AU - Kratimenos, Panagiotis

AU - Ishibashi, Nobuyuki

AU - Gallo, Vittorio

AU - Iwata, Osuke

AU - Saitoh, Shinji

AU - Khodosevich, Konstantin

AU - Sawamoto, Kazunobu

PY - 2025

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