Silencing Metabolic Disorders by Novel SIRT1 Activators

Kei Sakamoto

doi:10.1016/j.cmet.2007.12.005

Silencing Metabolic Disorders by Novel SIRT1 Activators

Kei Sakamoto^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Letter › Forskning › peer review

2 Citationer (Scopus)

Abstract

SIRT1, a NAD⁺-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.

Originalsprog	Engelsk
Tidsskrift	Cell Metabolism
Vol/bind	7
Udgave nummer	1
Sider (fra-til)	3-4
Antal sider	2
ISSN	1550-4131
DOI	https://doi.org/10.1016/j.cmet.2007.12.005
Status	Udgivet - 9 jan. 2008
Udgivet eksternt	Ja

Adgang til dokumentet

10.1016/j.cmet.2007.12.005

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Link to publication in Scopus

Citationsformater

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abstract = "SIRT1, a NAD+-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.",

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AB - SIRT1, a NAD+-dependent protein deacetylase that regulates transcription factors involved in key cellular processes, has been implicated as a mediator of the beneficial effects of calorie restriction. In a recent issue of Nature, Milne et al. (2007) describe novel potent activators of SIRT1, whose administration to insulin-resistant animals improves glucose homeostasis.

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