Simulating realistic membrane shapes

Weria Pezeshkian; Siewert J. Marrink

doi:10.1016/j.ceb.2021.02.009

Simulating realistic membrane shapes

Weria Pezeshkian
, Siewert J. Marrink^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Review › peer review

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Abstract

Biological membranes exhibit diversity in their shapes and complexity in chemical compositions that are linked to many cellular functions. These two central features of biomembranes have been the subject of numerous simulation studies, using a diverse range of computational techniques. Currently, the field is able to capture this complexity at increasing levels of realism and connect the microscopic view on protein-lipid interactions to cellular morphologies at the level of entire organelles. Here we highlight recent advances in this topic, identify current bottlenecks, and sketch possible ways ahead.

Originalsprog	Engelsk
Tidsskrift	Current Opinion in Cell Biology
Vol/bind	71
Sider (fra-til)	103-111
Antal sider	9
ISSN	0955-0674
DOI	https://doi.org/10.1016/j.ceb.2021.02.009
Status	Udgivet - 1 aug. 2021
Udgivet eksternt	Ja

Finansiering

This research is supported by the "BaSyCdBuilding a Synthetic Cell" Gravitation grant (024.003.019) of the Netherlands Ministry of Education, Culture, and Science (OCW) and the Netherlands Organization for Scientific Research (NWO). The authors thank Alex H. de Vries and Melanie Konig for their constructive comments.

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10.1016/j.ceb.2021.02.009Licens: CC BY

1-s2.0-S0955067421000302-mainForlagets udgivne version, 1,45 MBLicens: CC BY

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Citationsformater

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