Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells

Signe R Michaelsen; Camilla L Christensen; Maxwell Sehested; Frederik Cramer; Thomas T Poulsen; Adam V Patterson; Hans S Poulsen

doi:10.1002/jgm.2630

Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells

Signe R Michaelsen, Camilla L Christensen, Maxwell Sehested, Frederik Cramer, Thomas T Poulsen, Adam V Patterson, Hans S Poulsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

13 Citationer (Scopus)

Abstract

Transcriptional targeted suicide gene (SG) therapy driven by the insulinoma-associated 1 (INSM1) promoter makes it possible to target suicide toxin production and cytotoxicity exclusively to small cell lung cancer (SCLC) cells and tumors. It remains to be determined whether acquired chemoresistance, as observed in the majority of SCLC patients, desensitizes SCLC cells to INSM1 promoter-driven SG therapy.

Originalsprog	Engelsk
Tidsskrift	Journal of Gene Medicine (Online)
Vol/bind	14
Udgave nummer	7
Sider (fra-til)	445-58
Antal sider	14
ISSN	1099-498X
DOI	https://doi.org/10.1002/jgm.2630
Status	Udgivet - 2012

Adgang til dokumentet

10.1002/jgm.2630

Citationsformater

Single agent- and combination treatment with two targeted suicide gene therapy systems is effective in chemoresistant small cell lung cancer cells. / Michaelsen, Signe R; Christensen, Camilla L; Sehested, Maxwell et al.
I: Journal of Gene Medicine (Online), Bind 14, Nr. 7, 2012, s. 445-58.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

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abstract = "Transcriptional targeted suicide gene (SG) therapy driven by the insulinoma-associated 1 (INSM1) promoter makes it possible to target suicide toxin production and cytotoxicity exclusively to small cell lung cancer (SCLC) cells and tumors. It remains to be determined whether acquired chemoresistance, as observed in the majority of SCLC patients, desensitizes SCLC cells to INSM1 promoter-driven SG therapy.",

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AU - Poulsen, Thomas T

AU - Patterson, Adam V

AU - Poulsen, Hans S

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