Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study

Inger Christine Munch; Jakob Ek; Line Kessel; Birgit Sander; Gitte Juul Almind; Karen Brøndum-Nielsen; Allan Linneberg; Michael Larsen; Inger Christine Munch; Jakob Ek; Line Kessel; Birgit Sander; Gitte Juul Almind; Karen Brøndum-Nielsen; Allan Linneberg; Michael Larsen

doi:10.1167/iovs.09-4482

Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study

Inger Christine Munch, Jakob Ek, Line Kessel, Birgit Sander, Gitte Juul Almind, Karen Brøndum-Nielsen, Allan Linneberg, Michael Larsen, Inger Christine Munch, Jakob Ek, Line Kessel, Birgit Sander, Gitte Juul Almind, Karen Brøndum-Nielsen, Allan Linneberg, Michael Larsen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

40 Citationer (Scopus)

Abstract

Udgivelsesdato: 2010-May

Originalsprog	Engelsk
Tidsskrift	Investigative Ophthalmology & Visual Science
Vol/bind	51
Udgave nummer	5
Sider (fra-til)	2317-21
Antal sider	5
ISSN	0146-0404
DOI	https://doi.org/10.1167/iovs.09-4482 https://doi.org/10.1167/iovs.09-4482
Status	Udgivet - 1 maj 2010

Bibliografisk note

Keywords: Adult; Aged; Complement Factor B; Complement Factor H; Female; Genotype; Humans; Macular Degeneration; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proteins; Retinal Drusen

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Citationsformater

Munch, I. C., Ek, J., Kessel, L., Sander, B., Almind, G. J., Brøndum-Nielsen, K., Linneberg, A., Larsen, M., Munch, I. C., Ek, J., Kessel, L., Sander, B., Almind, G. J., Brøndum-Nielsen, K., Linneberg, A., & Larsen, M. (2010). Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study. Investigative Ophthalmology & Visual Science, 51(5), 2317-21. https://doi.org/10.1167/iovs.09-4482, https://doi.org/10.1167/iovs.09-4482

Munch, IC, Ek, J, Kessel, L, Sander, B, Almind, GJ, Brøndum-Nielsen, K, Linneberg, A , Larsen, M, Munch, IC, Ek, J, Kessel, L, Sander, B, Almind, GJ, Brøndum-Nielsen, K, Linneberg, A & Larsen, M 2010, 'Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study', Investigative Ophthalmology & Visual Science, bind 51, nr. 5, s. 2317-21. https://doi.org/10.1167/iovs.09-4482, https://doi.org/10.1167/iovs.09-4482

@article{95f1c54088cc11df928f000ea68e967b,

title = "Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study",

abstract = "PURPOSE: To study associations of small, hard macular drusen and peripheral drusen with genotypes associated with age-related macular degeneration (AMD). METHODS: Digital grayscale fundus photographs recorded in red-free illumination were graded for the presence of drusen in 1107 subjects aged 30 to 66 years. Participants were genotyped for AMD-related polymorphisms in complement factor H (CFH), in LOC387715, and in complement factor B (CFB). RESULTS: The prevalence of 20 or more small, hard macular drusen per eye was 14%, with no association to the investigated polymorphisms. Peripheral drusen were associated with CFHY402H (odds ratio [OR], 4.3; 95% confidence interval [95% CI], 1.4-13, for CC versus TT genotypes) as was macular drusen >63 microm (OR, 1.9; 95% CI, 1.1-3.1, for CC versus TT genotypes). Macular drusen >63 microm were associated with the presence of 20 or more small, hard macular drusen (OR, 1.7; 95% CI, 1.1-2.6) and with peripheral drusen (OR, 2.5; 95% CI,1.2-5.4) CONCLUSIONS: In this study, the presence of 20 or more small, hard macular drusen per eye was not associated with known AMD-related polymorphisms, whereas the study confirmed an association of peripheral drusen with CFHY402H. (ClinicalTrials.gov number, NCT00289237).",

author = "Munch, {Inger Christine} and Jakob Ek and Line Kessel and Birgit Sander and Almind, {Gitte Juul} and Karen Br{\o}ndum-Nielsen and Allan Linneberg and Michael Larsen and Munch, {Inger Christine} and Jakob Ek and Line Kessel and Birgit Sander and Almind, {Gitte Juul} and Karen Br{\o}ndum-Nielsen and Allan Linneberg and Michael Larsen",

note = "Keywords: Adult; Aged; Complement Factor B; Complement Factor H; Female; Genotype; Humans; Macular Degeneration; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proteins; Retinal Drusen",

year = "2010",

month = may,

day = "1",

doi = "10.1167/iovs.09-4482",

language = "English",

volume = "51",

pages = "2317--21",

journal = "Investigative Ophthalmology & Visual Science",

issn = "0146-0404",

publisher = "Association for Research in Vision and Ophthalmology",

number = "5",

}

TY - JOUR

T1 - Small, hard macular drusen and peripheral drusen: associations with AMD genotypes in the Inter99 Eye Study

AU - Munch, Inger Christine

AU - Ek, Jakob

AU - Kessel, Line

AU - Sander, Birgit

AU - Almind, Gitte Juul

AU - Brøndum-Nielsen, Karen

AU - Linneberg, Allan

AU - Larsen, Michael

AU - Munch, Inger Christine

AU - Ek, Jakob

AU - Kessel, Line

AU - Sander, Birgit

AU - Almind, Gitte Juul

AU - Brøndum-Nielsen, Karen

AU - Linneberg, Allan

AU - Larsen, Michael

N1 - Keywords: Adult; Aged; Complement Factor B; Complement Factor H; Female; Genotype; Humans; Macular Degeneration; Male; Middle Aged; Phenotype; Polymorphism, Single Nucleotide; Proteins; Retinal Drusen

PY - 2010/5/1

Y1 - 2010/5/1

N2 - PURPOSE: To study associations of small, hard macular drusen and peripheral drusen with genotypes associated with age-related macular degeneration (AMD). METHODS: Digital grayscale fundus photographs recorded in red-free illumination were graded for the presence of drusen in 1107 subjects aged 30 to 66 years. Participants were genotyped for AMD-related polymorphisms in complement factor H (CFH), in LOC387715, and in complement factor B (CFB). RESULTS: The prevalence of 20 or more small, hard macular drusen per eye was 14%, with no association to the investigated polymorphisms. Peripheral drusen were associated with CFHY402H (odds ratio [OR], 4.3; 95% confidence interval [95% CI], 1.4-13, for CC versus TT genotypes) as was macular drusen >63 microm (OR, 1.9; 95% CI, 1.1-3.1, for CC versus TT genotypes). Macular drusen >63 microm were associated with the presence of 20 or more small, hard macular drusen (OR, 1.7; 95% CI, 1.1-2.6) and with peripheral drusen (OR, 2.5; 95% CI,1.2-5.4) CONCLUSIONS: In this study, the presence of 20 or more small, hard macular drusen per eye was not associated with known AMD-related polymorphisms, whereas the study confirmed an association of peripheral drusen with CFHY402H. (ClinicalTrials.gov number, NCT00289237).

AB - PURPOSE: To study associations of small, hard macular drusen and peripheral drusen with genotypes associated with age-related macular degeneration (AMD). METHODS: Digital grayscale fundus photographs recorded in red-free illumination were graded for the presence of drusen in 1107 subjects aged 30 to 66 years. Participants were genotyped for AMD-related polymorphisms in complement factor H (CFH), in LOC387715, and in complement factor B (CFB). RESULTS: The prevalence of 20 or more small, hard macular drusen per eye was 14%, with no association to the investigated polymorphisms. Peripheral drusen were associated with CFHY402H (odds ratio [OR], 4.3; 95% confidence interval [95% CI], 1.4-13, for CC versus TT genotypes) as was macular drusen >63 microm (OR, 1.9; 95% CI, 1.1-3.1, for CC versus TT genotypes). Macular drusen >63 microm were associated with the presence of 20 or more small, hard macular drusen (OR, 1.7; 95% CI, 1.1-2.6) and with peripheral drusen (OR, 2.5; 95% CI,1.2-5.4) CONCLUSIONS: In this study, the presence of 20 or more small, hard macular drusen per eye was not associated with known AMD-related polymorphisms, whereas the study confirmed an association of peripheral drusen with CFHY402H. (ClinicalTrials.gov number, NCT00289237).

U2 - 10.1167/iovs.09-4482

DO - 10.1167/iovs.09-4482

M3 - Journal article

C2 - 20007824

SN - 0146-0404

VL - 51

SP - 2317

EP - 2321

JO - Investigative Ophthalmology & Visual Science

JF - Investigative Ophthalmology & Visual Science

IS - 5

ER -