Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Søren Lindberg; Sune H Pedersen; Rasmus Mogelvang; Søren Galatius; Allan Flyvbjerg; Jan Skov Jensen; Mette Bjerre

doi:10.1016/j.ahj.2012.08.018

Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

Søren Lindberg, Sune H Pedersen, Rasmus Mogelvang, Søren Galatius, Allan Flyvbjerg, Jan Skov Jensen, Mette Bjerre

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

25 Citationer (Scopus)

Abstract

The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).

Originalsprog	Engelsk
Tidsskrift	American Heart Journal
Vol/bind	164
Udgave nummer	5
Sider (fra-til)	786-92
Antal sider	7
ISSN	0002-8703
DOI	https://doi.org/10.1016/j.ahj.2012.08.018
Status	Udgivet - 2012

Adgang til dokumentet

10.1016/j.ahj.2012.08.018

Citationsformater

Lindberg, S., Pedersen, S. H., Mogelvang, R., Galatius, S., Flyvbjerg, A., Jensen, J. S., & Bjerre, M. (2012). Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. American Heart Journal, 164(5), 786-92. https://doi.org/10.1016/j.ahj.2012.08.018

Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention. / Lindberg, Søren; Pedersen, Sune H; Mogelvang, Rasmus et al.
I: American Heart Journal, Bind 164, Nr. 5, 2012, s. 786-92.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Lindberg, S, Pedersen, SH, Mogelvang, R, Galatius, S, Flyvbjerg, A, Jensen, JS & Bjerre, M 2012, 'Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention', American Heart Journal, bind 164, nr. 5, s. 786-92. https://doi.org/10.1016/j.ahj.2012.08.018

@article{12c98401224b4c5b9e810fd1c5f5ed73,

title = "Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention",

abstract = "The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).",

author = "S{\o}ren Lindberg and Pedersen, {Sune H} and Rasmus Mogelvang and S{\o}ren Galatius and Allan Flyvbjerg and Jensen, {Jan Skov} and Mette Bjerre",

year = "2012",

doi = "10.1016/j.ahj.2012.08.018",

language = "English",

volume = "164",

pages = "786--92",

journal = "American Heart Journal",

issn = "0002-8703",

publisher = "Mosby Inc.",

number = "5",

}

TY - JOUR

T1 - Soluble form of membrane attack complex independently predicts mortality and cardiovascular events in patients with ST-elevation myocardial infarction treated with primary percutaneous coronary intervention

AU - Lindberg, Søren

AU - Pedersen, Sune H

AU - Mogelvang, Rasmus

AU - Galatius, Søren

AU - Flyvbjerg, Allan

AU - Jensen, Jan Skov

AU - Bjerre, Mette

PY - 2012

Y1 - 2012

N2 - The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).

AB - The complement system is an important mediator of inflammation, which plays a pivotal role in atherosclerosis and acute myocardial infarction (AMI). Animal studies suggest that activation of the complement cascade resulting in the formation of soluble membrane attack complex (sMAC), contributes to both atherosclerosis and plaque rupture and may be the direct cause of tissue damage related to ischemia/reperfusion injury. However clinical data of sMAC during an AMI is sparse. Accordingly the aim was to investigate the prognostic role of sMAC in patients with ST-segment elevation myocardial infarction (STEMI).

U2 - 10.1016/j.ahj.2012.08.018

DO - 10.1016/j.ahj.2012.08.018

M3 - Journal article

C2 - 23137511

SN - 0002-8703

VL - 164

SP - 786

EP - 792

JO - American Heart Journal

JF - American Heart Journal

IS - 5

ER -