Spaedbørnsdiabetes kan ofte behandles med sulfonylurinstof i stedet for insulin

Mette Høj Lauridsen, Trine Welløv Boesgaard, Oluf Pedersen, Torben Hansen, Birgitte Hertz

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Abstract

A two-month-old Danish girl was admitted to the hospital in diabetic ketoacidosis and diagnosed with permanent neonatal diabetes mellitus (PNDM). She received continuous insulin treatment until she was genetically tested at the Steno Diabetes Centre. She carried a KCNJ11 Arg201His mutation, an activating mutation in the KCNJ11-gene which encodes the ATP-sensitive potassium subunit Kir6.2 in the beta cell which is responsible for insulin secretion. As recommended in the literature, she was successfully shifted from insulin therapy to sulfonylurea tablets at the age of three years and nine months. PNDM-patients should be screened for gene mutations regardless of current age.
Udgivelsesdato: 2009-Jun-1
Bidragets oversatte titelDiabetes in infants may be treated with sulfonylurea as a replacement for insulin
OriginalsprogDansk
TidsskriftUgeskrift for læger
Vol/bind171
Udgave nummer23
Sider (fra-til)1923-4
Antal sider1
ISSN0041-5782
StatusUdgivet - 2009

Bibliografisk note

Keywords: Child, Preschool; Diabetes Mellitus, Type 1; Diabetic Ketoacidosis; Female; Glyburide; Humans; Hypoglycemic Agents; Infant; Insulin; Mutation; Potassium Channels, Inwardly Rectifying; Treatment Outcome

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