@article{999d3bb0a07111dd86a6000ea68e967b,
title = "Specific T-cell recognition of the merozoite proteins rhoptry-associated protein 1 and erythrocyte-binding antigen 1 of Plasmodium falciparum",
abstract = "The merozoite proteins merozoite surface protein 1 (MSP-1) and rhoptry-associated protein 1 (RAP-1) and synthetic peptides containing sequences of MSP-1, RAP-1, and erythrocyte-binding antigen 1, induced in vitro proliferative responses of lymphocytes collected from Ghanaian blood donors living in an area with a high rate of transmission of malaria. Lymphocytes from a large proportion of the Ghanaian blood donors proliferated in response to the RAP-1 peptide, unlike those of Danish control blood donors, indicating that this sequence contains a malaria-specific T-cell epitope broadly recognized by individuals living in an area with a high transmission rate of malaria. Most of the donor plasma samples tested contained immunoglobulin G (IgG) and IgM antibodies recognizing the merozoite proteins, while only a minority showed high IgG reactivity to the synthetic peptides.",
author = "Jakobsen, {P H} and L Hviid and Theander, {T G} and Afare, {E A} and Ridley, {R G} and Heegaard, {P M} and D Stuber and K Dalsgaard and Nkrumah, {F K}",
note = "Keywords: Adolescent; Adult; Amino Acid Sequence; Antigens, Protozoan; Antigens, Surface; Carrier Proteins; Child; Child, Preschool; Enzyme-Linked Immunosorbent Assay; Humans; Immunity, Cellular; Immunoglobulin G; Immunoglobulin M; Lymphocyte Activation; Malaria, Falciparum; Merozoite Surface Protein 1; Middle Aged; Molecular Sequence Data; Protein Precursors; Protozoan Proteins; Receptors, Cell Surface; T-Lymphocytes",
year = "1993",
language = "English",
volume = "61",
pages = "268--73",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "1",
}