Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis

H Ring-Larsen; I L Kanstrup; N J Christensen; Jens Henrik Sahl Henriksen

Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis

H Ring-Larsen, I L Kanstrup, N J Christensen, Jens Henrik Sahl Henriksen

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

183 Citationer (Scopus)

Abstract

Udgivelsesdato: 1984-Oct

Originalsprog	Engelsk
Tidsskrift	Gut
Vol/bind	25
Udgave nummer	10
Sider (fra-til)	1034-43
Antal sider	9
ISSN	0017-5749
Status	Udgivet - 1984

Bibliografisk note

Keywords: Adult; Aged; Epinephrine; Female; Femoral Artery; Hemodynamics; Hepatic Veins; Humans; Kidney; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Renal Veins; Splanchnic Circulation; Sympathetic Nervous System

Citationsformater

@article{8ca2e360461f11df928f000ea68e967b,

title = "Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis",

abstract = "Plasma noradrenaline (NA) and adrenaline (A) concentrations were determined in different vascular areas in 32 patients with cirrhosis and in nine controls during a right sided heart, liver, and renal vein catheterisation. The patients were divided into four groups: (I) Compensated (without ascites); (II) Recompensated on diuretic treatment because of former ascites; (III) Decompensated (with ascites) without treatment and (IV) Decompensated on diuretic treatment. Median arterial noradrenaline concentrations were 1.48, 1.07, 2.66, 4.14 and 2.50 nmol/l in controls, group I, II, III, and IV, respectively, the three last mentioned values being significantly raised (p less than 0.01). Median arterial adrenaline concentrations were not significantly increased. In patients arterial-hepatic venous extraction ratios of noradrenaline and adrenaline were on the average 25% (p less than 0.01) and 20% (p less than 0.02) less than those of the controls, indicating a slightly reduced splanchnic elimination of catecholamines in cirrhoses. In controls and group I significant renal venous-arterial noradrenaline differences were absent (0.00 and 0.03 nmol/l) while renal venous-arterial noradrenaline differences were significantly increased in groups II, III and IV (0.47, 0.53 and 0.68 nmol/l, p less than 0.01), indicating a significant net release of noradrenaline from the kidneys in recompensated and decompensated patients. Renal extraction of adrenaline was normal. In conclusion, increased arterial noradrenaline in decompensated and recompensated cirrhosis is only to a limited extent owing to reduced net splanchnic elimination. More likely the increase is caused by release of noradrenaline from the kidneys and possibly other organs indicating enhanced sympathetic nervous tone in these conditions.",

author = "H Ring-Larsen and Kanstrup, {I L} and Christensen, {N J} and Henriksen, {Jens Henrik Sahl}",

note = "Keywords: Adult; Aged; Epinephrine; Female; Femoral Artery; Hemodynamics; Hepatic Veins; Humans; Kidney; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Renal Veins; Splanchnic Circulation; Sympathetic Nervous System",

year = "1984",

language = "English",

volume = "25",

pages = "1034--43",

journal = "Gut",

issn = "0017-5749",

publisher = "B M J Group",

number = "10",

}

TY - JOUR

T1 - Splanchnic and renal elimination and release of catecholamines in cirrhosis. Evidence of enhanced sympathetic nervous activity in patients with decompensated cirrhosis

AU - Ring-Larsen, H

AU - Kanstrup, I L

AU - Christensen, N J

AU - Henriksen, Jens Henrik Sahl

N1 - Keywords: Adult; Aged; Epinephrine; Female; Femoral Artery; Hemodynamics; Hepatic Veins; Humans; Kidney; Liver Cirrhosis; Male; Middle Aged; Norepinephrine; Renal Veins; Splanchnic Circulation; Sympathetic Nervous System

PY - 1984

Y1 - 1984

N2 - Plasma noradrenaline (NA) and adrenaline (A) concentrations were determined in different vascular areas in 32 patients with cirrhosis and in nine controls during a right sided heart, liver, and renal vein catheterisation. The patients were divided into four groups: (I) Compensated (without ascites); (II) Recompensated on diuretic treatment because of former ascites; (III) Decompensated (with ascites) without treatment and (IV) Decompensated on diuretic treatment. Median arterial noradrenaline concentrations were 1.48, 1.07, 2.66, 4.14 and 2.50 nmol/l in controls, group I, II, III, and IV, respectively, the three last mentioned values being significantly raised (p less than 0.01). Median arterial adrenaline concentrations were not significantly increased. In patients arterial-hepatic venous extraction ratios of noradrenaline and adrenaline were on the average 25% (p less than 0.01) and 20% (p less than 0.02) less than those of the controls, indicating a slightly reduced splanchnic elimination of catecholamines in cirrhoses. In controls and group I significant renal venous-arterial noradrenaline differences were absent (0.00 and 0.03 nmol/l) while renal venous-arterial noradrenaline differences were significantly increased in groups II, III and IV (0.47, 0.53 and 0.68 nmol/l, p less than 0.01), indicating a significant net release of noradrenaline from the kidneys in recompensated and decompensated patients. Renal extraction of adrenaline was normal. In conclusion, increased arterial noradrenaline in decompensated and recompensated cirrhosis is only to a limited extent owing to reduced net splanchnic elimination. More likely the increase is caused by release of noradrenaline from the kidneys and possibly other organs indicating enhanced sympathetic nervous tone in these conditions.

AB - Plasma noradrenaline (NA) and adrenaline (A) concentrations were determined in different vascular areas in 32 patients with cirrhosis and in nine controls during a right sided heart, liver, and renal vein catheterisation. The patients were divided into four groups: (I) Compensated (without ascites); (II) Recompensated on diuretic treatment because of former ascites; (III) Decompensated (with ascites) without treatment and (IV) Decompensated on diuretic treatment. Median arterial noradrenaline concentrations were 1.48, 1.07, 2.66, 4.14 and 2.50 nmol/l in controls, group I, II, III, and IV, respectively, the three last mentioned values being significantly raised (p less than 0.01). Median arterial adrenaline concentrations were not significantly increased. In patients arterial-hepatic venous extraction ratios of noradrenaline and adrenaline were on the average 25% (p less than 0.01) and 20% (p less than 0.02) less than those of the controls, indicating a slightly reduced splanchnic elimination of catecholamines in cirrhoses. In controls and group I significant renal venous-arterial noradrenaline differences were absent (0.00 and 0.03 nmol/l) while renal venous-arterial noradrenaline differences were significantly increased in groups II, III and IV (0.47, 0.53 and 0.68 nmol/l, p less than 0.01), indicating a significant net release of noradrenaline from the kidneys in recompensated and decompensated patients. Renal extraction of adrenaline was normal. In conclusion, increased arterial noradrenaline in decompensated and recompensated cirrhosis is only to a limited extent owing to reduced net splanchnic elimination. More likely the increase is caused by release of noradrenaline from the kidneys and possibly other organs indicating enhanced sympathetic nervous tone in these conditions.

M3 - Journal article

C2 - 6479678

SN - 0017-5749

VL - 25

SP - 1034

EP - 1043

JO - Gut

JF - Gut

IS - 10

ER -