@article{bd232aa0a05f11df928f000ea68e967b,
title = "Src homology 2 domain-containing inositol-5-phosphatase and CCAAT enhancer-binding protein beta are targeted by miR-155 in B cells of Emicro-MiR-155 transgenic mice",
abstract = "We showed that Emicro-MiR-155 transgenic mice develop acute lymphoblastic leukemia/high-grade lymphoma. Most of these leukemias start at approximately 9 months irrespective of the mouse strain. They are preceded by a polyclonal pre-B-cell proliferation, have variable clinical presentation, are transplantable, and develop oligo/monoclonal expansion. In this study, we show that in these transgenic mice the B-cell precursors have the highest MiR-155 transgene expression and are at the origin of the leukemias. We determine that Src homology 2 domain-containing inositol-5-phosphatase (SHIP) and CCAAT enhancer-binding protein beta (C/EBPbeta), 2 important regulators of the interleukin-6 signaling pathway, are direct targets of MiR-155 and become gradually more down-regulated in the leukemic than in the preleukemic mice. We hypothesize that miR-155, by down-modulating Ship and C/EBPbeta, initiates a chain of events that leads to the accumulation of large pre-B cells and acute lymphoblastic leukemia/high-grade lymphoma.",
author = "Stefan Costinean and Sandhu, {Sukhinder K} and Pedersen, {Irene M} and Esmerina Tili and Rossana Trotta and Danilo Perrotti and David Ciarlariello and Paolo Neviani and Jason Harb and Kauffman, {Lauren Rachel} and Aaditya Shidham and Croce, {Carlo Maria}",
note = "Keywords: Animals; CCAAT-Enhancer-Binding Protein-beta; Cell Transformation, Neoplastic; Down-Regulation; Gene Expression Regulation, Leukemic; Interleukin-6; Lymphoma, B-Cell; Mice; Mice, Transgenic; MicroRNAs; Phosphoric Monoester Hydrolases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor Cells, B-Lymphoid; Signal Transduction",
year = "2009",
doi = "10.1182/blood-2009-05-220814",
language = "English",
volume = "114",
pages = "1374--82",
journal = "Blood",
issn = "0006-4971",
publisher = "American Society of Hematology",
number = "7",
}