TY - JOUR
T1 - Stem cell therapy for Parkinson's disease: where do we stand?
AU - Roybon, Laurent
AU - Christophersen, Nicolaj S
AU - Brundin, Patrik
AU - Li, Jia-Yi
N1 - Keywords: Animals; Humans; Parkinson Disease; Stem Cell Transplantation
PY - 2004
Y1 - 2004
N2 - A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.
AB - A major neuropathological feature of Parkinson's disease (PD) is the loss of nigrostriatal dopaminergic neuron. Patients exhibit motor symptoms, including bradykinesia, rigidity, and tremor. Neural grafting has been reported to restore striatial dopaminergic neurotransmission and induce symptomatic relief. The major limitation of cell replacement therapy for PD is the shortage of suitable donor tissue. The present review describes the possible sources of cells, including embryonic stem cells and somatic adult stem cells, both of which potentially could be used in cell therapy for PD, and discusses the advantages and disadvantages of each cell type.
U2 - 10.1007/s00441-004-0946-y
DO - 10.1007/s00441-004-0946-y
M3 - Review
C2 - 15309619
VL - 318
SP - 261
EP - 273
JO - Cell and Tissue Research
JF - Cell and Tissue Research
SN - 0302-766X
IS - 1
ER -