Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

A Sette; S Buus; S Colon; J A Smith; C Miles; H M Grey

doi:10.1038/328395a0

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

A Sette, S Buus, S Colon, J A Smith, C Miles, H M Grey

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

392 Citationer (Scopus)

Abstract

Udgivelsesdato: null-null

Originalsprog	Engelsk
Tidsskrift	Nature
Vol/bind	328
Udgave nummer	6129
Sider (fra-til)	395-9
Antal sider	4
ISSN	0028-0836
DOI	https://doi.org/10.1038/328395a0
Status	Udgivet - 1987

Bibliografisk note

Keywords: Amino Acid Sequence; Animals; Antigens; Binding, Competitive; Histocompatibility Antigens Class II; Hybridomas; Ovalbumin; Peptide Fragments; Peptides; Structure-Activity Relationship; T-Lymphocytes

Adgang til dokumentet

10.1038/328395a0

Citationsformater

@article{857c9e70ebce11ddbf70000ea68e967b,

title = "Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells",

abstract = "A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.",

author = "A Sette and S Buus and S Colon and Smith, {J A} and C Miles and Grey, {H M}",

note = "Keywords: Amino Acid Sequence; Animals; Antigens; Binding, Competitive; Histocompatibility Antigens Class II; Hybridomas; Ovalbumin; Peptide Fragments; Peptides; Structure-Activity Relationship; T-Lymphocytes",

year = "1987",

doi = "10.1038/328395a0",

language = "English",

volume = "328",

pages = "395--9",

journal = "Nature",

issn = "0028-0836",

publisher = "nature publishing group",

number = "6129",

}

TY - JOUR

T1 - Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells

AU - Sette, A

AU - Buus, S

AU - Colon, S

AU - Smith, J A

AU - Miles, C

AU - Grey, H M

N1 - Keywords: Amino Acid Sequence; Animals; Antigens; Binding, Competitive; Histocompatibility Antigens Class II; Hybridomas; Ovalbumin; Peptide Fragments; Peptides; Structure-Activity Relationship; T-Lymphocytes

PY - 1987

Y1 - 1987

N2 - A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

AB - A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

U2 - 10.1038/328395a0

DO - 10.1038/328395a0

M3 - Journal article

C2 - 3497349

SN - 0028-0836

VL - 328

SP - 395

EP - 399

JO - Nature

JF - Nature

IS - 6129

ER -