Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Javier Macías-León; Iris A Bermejo; Alicia Asín; Ana García-García; Ismael Compañón; Ester Jiménez-Moreno; Helena Coelho; Vincenzo Mangini; Inês S Albuquerque; Filipa Marcelo; Juan L Asensio; Gonçalo J L Bernardes; Hiren J Joshi; Roberto Fiammengo; Ola Blixt; Ramón Hurtado-Guerrero; Francisco Corzana

doi:10.1039/d0cc06349e

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody

Javier Macías-León, Iris A Bermejo, Alicia Asín, Ana García-García, Ismael Compañón, Ester Jiménez-Moreno, Helena Coelho, Vincenzo Mangini, Inês S Albuquerque, Filipa Marcelo, Juan L Asensio, Gonçalo J L Bernardes, Hiren J Joshi, Roberto Fiammengo, Ola Blixt, Ramón Hurtado-Guerrero, Francisco Corzana

Glycomics Program

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

11 Citationer (Scopus)

16 Downloads (Pure)

Abstract

The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.

Originalsprog	Engelsk
Tidsskrift	Chemical communications (Cambridge, England)
Vol/bind	56
Udgave nummer	96
Sider (fra-til)	15137-15140
Antal sider	4
ISSN	1359-7345
DOI	https://doi.org/10.1039/d0cc06349e
Status	Udgivet - 2020

Adgang til dokumentet

10.1039/d0cc06349e

Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody_(accepted_version)Accepteret manuskript, 1,38 MB

Citationsformater

Macías-León, J., Bermejo, I. A., Asín, A., García-García, A., Compañón, I., Jiménez-Moreno, E., Coelho, H., Mangini, V., Albuquerque, I. S., Marcelo, F., Asensio, J. L., Bernardes, G. J. L., Joshi, H. J., Fiammengo, R., Blixt, O., Hurtado-Guerrero, R., & Corzana, F. (2020). Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody. Chemical communications (Cambridge, England), 56(96), 15137-15140. https://doi.org/10.1039/d0cc06349e

Macías-León, J, Bermejo, IA, Asín, A, García-García, A, Compañón, I, Jiménez-Moreno, E, Coelho, H, Mangini, V, Albuquerque, IS, Marcelo, F, Asensio, JL, Bernardes, GJL, Joshi, HJ, Fiammengo, R, Blixt, O, Hurtado-Guerrero, R & Corzana, F 2020, 'Structural characterization of an unprecedented lectin-like antitumoral anti-MUC1 antibody', Chemical communications (Cambridge, England), bind 56, nr. 96, s. 15137-15140. https://doi.org/10.1039/d0cc06349e

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abstract = "The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.",

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AU - Macías-León, Javier

AU - Bermejo, Iris A

AU - Asín, Alicia

AU - García-García, Ana

AU - Compañón, Ismael

AU - Jiménez-Moreno, Ester

AU - Coelho, Helena

AU - Mangini, Vincenzo

AU - Albuquerque, Inês S

AU - Marcelo, Filipa

AU - Asensio, Juan L

AU - Bernardes, Gonçalo J L

AU - Joshi, Hiren J

AU - Fiammengo, Roberto

AU - Blixt, Ola

AU - Hurtado-Guerrero, Ramón

AU - Corzana, Francisco

PY - 2020

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AB - The molecular basis of antibody 5E5, which recognizes the entire GalNAc unit as a primary epitope is disclosed. The antibody's contacts with the peptide are mostly limited to two residues, allowing it to show some degree of promiscuity. These findings open the door to the chemical design of peptide-mimetics for developing efficient anti-cancer vaccines and diagnostic tools.

U2 - 10.1039/d0cc06349e

DO - 10.1039/d0cc06349e

M3 - Journal article

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JO - Chemical communications (Cambridge, England)

JF - Chemical communications (Cambridge, England)

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