Structure, biosynthesis, and occurrence of bacterial pyrrolizidine alkaloids

Olivia Schimming; Victoria Louise Challinor; Nicholas J Tobias; Hélène Adihou; Peter Grün; Laura Pöschel; Christian Richter; Harald Schwalbe; Helge B. Bode

doi:10.1002/anie.201504877

Structure, biosynthesis, and occurrence of bacterial pyrrolizidine alkaloids

Olivia Schimming, Victoria Louise Challinor, Nicholas J Tobias, Hélène Adihou, Peter Grün, Laura Pöschel, Christian Richter, Harald Schwalbe, Helge B. Bode

Publikation: Bidrag til tidsskrift › Letter › peer review

44 Citationer (Scopus)

Abstract

Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.

Originalsprog	Engelsk
Tidsskrift	Angewandte Chemie International Edition
Vol/bind	54
Udgave nummer	43
Sider (fra-til)	12702-12705
Antal sider	4
ISSN	1433-7851
DOI	https://doi.org/10.1002/anie.201504877
Status	Udgivet - 2015
Udgivet eksternt	Ja

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10.1002/anie.201504877

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Citationsformater

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title = "Structure, biosynthesis, and occurrence of bacterial pyrrolizidine alkaloids",

abstract = "Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.",

keywords = "Bacteria, Bacterial Proteins, Biosynthetic Pathways, Magnetic Resonance Spectroscopy, Oxidation-Reduction, Peptide Synthases, Pyrrolizidine Alkaloids, Xenorhabdus, Journal Article, Research Support, Non-U.S. Gov't",

author = "Olivia Schimming and Challinor, {Victoria Louise} and Tobias, {Nicholas J} and H{\'e}l{\`e}ne Adihou and Peter Gr{\"u}n and Laura P{\"o}schel and Christian Richter and Harald Schwalbe and Bode, {Helge B.}",

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year = "2015",

doi = "10.1002/anie.201504877",

language = "English",

volume = "54",

pages = "12702--12705",

journal = "Angewandte Chemie International Edition",

issn = "1433-7851",

publisher = "Wiley-VCH Verlag GmbH & Co. KGaA",

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TY - JOUR

T1 - Structure, biosynthesis, and occurrence of bacterial pyrrolizidine alkaloids

AU - Schimming, Olivia

AU - Challinor, Victoria Louise

AU - Tobias, Nicholas J

AU - Adihou, Hélène

AU - Grün, Peter

AU - Pöschel, Laura

AU - Richter, Christian

AU - Schwalbe, Harald

AU - Bode, Helge B.

PY - 2015

Y1 - 2015

N2 - Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.

AB - Pyrrolizidine alkaloids (PAs) are widespread plant natural products with potent toxicity and bioactivity. Herein, the identification of bacterial PAs from entomopathogenic bacteria using differential analysis by 2D NMR spectroscopy (DANS) and mass spectrometry is described. Their biosynthesis was elucidated to involve a non-ribosomal peptide synthetase. The occurrence of these biosynthesis gene clusters in Gram-negative and Gram-positive bacteria indicates an important biological function in bacteria.

KW - Bacteria

KW - Bacterial Proteins

KW - Biosynthetic Pathways

KW - Magnetic Resonance Spectroscopy

KW - Oxidation-Reduction

KW - Peptide Synthases

KW - Pyrrolizidine Alkaloids

KW - Xenorhabdus

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1002/anie.201504877

DO - 10.1002/anie.201504877

M3 - Letter

C2 - 26465655

SN - 1433-7851

VL - 54

SP - 12702

EP - 12705

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 43

ER -