TY - JOUR
T1 - Structure of rat acidic fibroblast growth factor at 1.4 A resolution.
AU - Kulahin, Nikolaj
AU - Kiselyov, Vladislav
AU - Kochoyan, Artur
AU - Kristensen, Ole
AU - Kastrup, Jette Sandholm Jensen
AU - Berezin, Vladimir
AU - Bock, Elisabeth Marianne
AU - Gajhede, Michael
N1 - Paper id:: 17277441
PY - 2007
Y1 - 2007
N2 - Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.
AB - Fibroblast growth factors (FGFs) constitute a family of 22 structurally related heparin-binding polypeptides that are involved in the regulation of cell growth, survival, differentiation and migration. Here, a 1.4 A resolution X-ray structure of rat FGF1 is presented. Two molecules are present in the asymmetric unit of the crystal and they coordinate a total of five sulfate ions. The structures of human, bovine and newt FGF1 have been published previously. Human and rat FGF1 are found to have very similar structures.
U2 - 10.1107/S1744309107003144
DO - 10.1107/S1744309107003144
M3 - Journal article
C2 - 17277441
SN - 1744-3091
VL - 63
SP - 65
EP - 68
JO - Acta Crystallographica. Section F : Structural Biology and Crystallization Communications
JF - Acta Crystallographica. Section F : Structural Biology and Crystallization Communications
IS - Pt2
ER -