TY - JOUR
T1 - Studying Microstructure in Molecular Crystals With Nanoindentation
T2 - Intergrowth Polymorphism in Felodipine
AU - Mishra, Manish Kumar
AU - Desiraju, Gautam R
AU - Ramamurty, Upadrasta
AU - Bond, Andrew D
N1 - © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2014/9/26
Y1 - 2014/9/26
N2 - Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.
AB - Intergrowth polymorphism refers to the existence of distinct structural domains within a single crystal of a compound. The phenomenon is exhibited by form II of the active pharmaceutical ingredient felodipine, and the associated microstructure is a significant feature of the compound's structural identity. Employing the technique of nanoindentation on form II reveals a bimodal mechanical response on specific single-crystal faces, demonstrating distinct properties for two polymorphic forms within the same crystal.
U2 - 10.1002/anie.201406898
DO - 10.1002/anie.201406898
M3 - Journal article
C2 - 25264144
SN - 1433-7851
VL - 53
SP - 13102
EP - 13105
JO - Angewandte Chemie (International ed. in English)
JF - Angewandte Chemie (International ed. in English)
IS - 48
ER -