Subcellular localization of YKL-40 in normal and malignant epithelial cells of the breast

A. Roslind; E. Balslev; H. Kruse; B. Staergaard; T. Horn

Subcellular localization of YKL-40 in normal and malignant epithelial cells of the breast

A. Roslind, E. Balslev, H. Kruse, B. Staergaard, T. Horn

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

6 Citationer (Scopus)

Abstract

YKL-40 is a new prognostic biomarker in cancer. The biological function is only poorly understood. This study aimed at determining the subcellular localization of YKL-40, using immunogold labeling, in normal epithelial cells and in malignant tumor cells of the breast by immunoelectron microscopy. YKL-40 protein expression was redistributed in carcinoma versus normal glandular tissue of the breast. A reduced expression of YKL-40 in relation to intermediate filaments and desmosomes was found in tumor cells. Changes in YKL-40 expression suggest that the function of YKL-40 in cells of epithelial origin may be related to cell motility and cell-cell adhesion, features associated with invasion and migration potential of tumor cells
Udgivelsesdato: 2008

Originalsprog	Engelsk
Tidsskrift	Ultrastructural Pathology
Vol/bind	32
Udgave nummer	3
Sider (fra-til)	101-106
Antal sider	5
ISSN	0191-3123
Status	Udgivet - 2008

Bibliografisk note

Times Cited: 0ArticleEnglishRoslind, AHerlev Univ Hosp, Dept Oncol, Herlev Ringvej 75, DK-2730 Copenhagen, DenmarkCited References Count: 35318INTAYLOR & FRANCIS INC325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAPHILADELPHIA

Citationsformater

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title = "Subcellular localization of YKL-40 in normal and malignant epithelial cells of the breast",

abstract = "YKL-40 is a new prognostic biomarker in cancer. The biological function is only poorly understood. This study aimed at determining the subcellular localization of YKL-40, using immunogold labeling, in normal epithelial cells and in malignant tumor cells of the breast by immunoelectron microscopy. YKL-40 protein expression was redistributed in carcinoma versus normal glandular tissue of the breast. A reduced expression of YKL-40 in relation to intermediate filaments and desmosomes was found in tumor cells. Changes in YKL-40 expression suggest that the function of YKL-40 in cells of epithelial origin may be related to cell motility and cell-cell adhesion, features associated with invasion and migration potential of tumor cells Udgivelsesdato: 2008",

author = "A. Roslind and E. Balslev and H. Kruse and B. Staergaard and T. Horn",

note = "Times Cited: 0ArticleEnglishRoslind, AHerlev Univ Hosp, Dept Oncol, Herlev Ringvej 75, DK-2730 Copenhagen, DenmarkCited References Count: 35318INTAYLOR & FRANCIS INC325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAPHILADELPHIA",

year = "2008",

language = "English",

volume = "32",

pages = "101--106",

journal = "Ultrastructural Pathology",

issn = "0191-3123",

publisher = "Taylor & Francis",

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TY - JOUR

T1 - Subcellular localization of YKL-40 in normal and malignant epithelial cells of the breast

AU - Roslind, A.

AU - Balslev, E.

AU - Kruse, H.

AU - Staergaard, B.

AU - Horn, T.

N1 - Times Cited: 0ArticleEnglishRoslind, AHerlev Univ Hosp, Dept Oncol, Herlev Ringvej 75, DK-2730 Copenhagen, DenmarkCited References Count: 35318INTAYLOR & FRANCIS INC325 CHESTNUT ST, SUITE 800, PHILADELPHIA, PA 19106 USAPHILADELPHIA

PY - 2008

Y1 - 2008

N2 - YKL-40 is a new prognostic biomarker in cancer. The biological function is only poorly understood. This study aimed at determining the subcellular localization of YKL-40, using immunogold labeling, in normal epithelial cells and in malignant tumor cells of the breast by immunoelectron microscopy. YKL-40 protein expression was redistributed in carcinoma versus normal glandular tissue of the breast. A reduced expression of YKL-40 in relation to intermediate filaments and desmosomes was found in tumor cells. Changes in YKL-40 expression suggest that the function of YKL-40 in cells of epithelial origin may be related to cell motility and cell-cell adhesion, features associated with invasion and migration potential of tumor cells Udgivelsesdato: 2008

AB - YKL-40 is a new prognostic biomarker in cancer. The biological function is only poorly understood. This study aimed at determining the subcellular localization of YKL-40, using immunogold labeling, in normal epithelial cells and in malignant tumor cells of the breast by immunoelectron microscopy. YKL-40 protein expression was redistributed in carcinoma versus normal glandular tissue of the breast. A reduced expression of YKL-40 in relation to intermediate filaments and desmosomes was found in tumor cells. Changes in YKL-40 expression suggest that the function of YKL-40 in cells of epithelial origin may be related to cell motility and cell-cell adhesion, features associated with invasion and migration potential of tumor cells Udgivelsesdato: 2008

M3 - Journal article

SN - 0191-3123

VL - 32

SP - 101

EP - 106

JO - Ultrastructural Pathology

JF - Ultrastructural Pathology

IS - 3

ER -