TY - JOUR
T1 - Subnets of scale-free networks are not scale-free
T2 - Sampling properties of networks
AU - Stumpf, Michael P.H.
AU - Wiuf, Carsten
AU - May, Robert M.
PY - 2005/3/22
Y1 - 2005/3/22
N2 - Most studies of networks have only looked at small subsets of the true network. Here, we discuss the sampling properties of a network's degree distribution under the most parsimonious sampling scheme. Only if the degree distributions of the network and randomly sampled subnets belong to the same family of probability distributions is it possible to extrapolate from subnet data to properties of the global network. We show that this condition is indeed satisfied for some important classes of networks, notably classical random graphs and exponential random graphs. For scale-free degree distributions, however, this is not the case. Thus, inferences about the scale-free nature of a network may have to be treated with some caution. The work presented here has important implications for the analysis of molecular networks as well as for graph theory and the theory of networks in general.
AB - Most studies of networks have only looked at small subsets of the true network. Here, we discuss the sampling properties of a network's degree distribution under the most parsimonious sampling scheme. Only if the degree distributions of the network and randomly sampled subnets belong to the same family of probability distributions is it possible to extrapolate from subnet data to properties of the global network. We show that this condition is indeed satisfied for some important classes of networks, notably classical random graphs and exponential random graphs. For scale-free degree distributions, however, this is not the case. Thus, inferences about the scale-free nature of a network may have to be treated with some caution. The work presented here has important implications for the analysis of molecular networks as well as for graph theory and the theory of networks in general.
KW - Complex networks
KW - Protein interaction networks
KW - Random graphs
KW - Sampling theory
UR - http://www.scopus.com/inward/record.url?scp=15444372528&partnerID=8YFLogxK
U2 - 10.1073/pnas.0501179102
DO - 10.1073/pnas.0501179102
M3 - Journal article
AN - SCOPUS:15444372528
VL - 102
SP - 4221
EP - 4224
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 12
ER -