Abstract
BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.
METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.
RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints.
CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | e002470 |
| Tidsskrift | Circulation. Genomic and precision medicine |
| Vol/bind | 12 |
| Udgave nummer | 4 |
| Sider (fra-til) | 145-160 |
| ISSN | 2574-8300 |
| DOI | |
| Status | Udgivet - apr. 2019 |
Adgang til dokumentet
- 10.1161/CIRCGEN.119.002470Licens: CC BY
- Subsequent Event Risk in Individuals With Established Coronary Heart DiseaseForlagets udgivne version, 640 KBLicens: CC BY
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Subsequent Event Risk in Individuals with Established Coronary Heart Disease : Design and Rationale of the GENIUS-CHD Consortium. / Patel, Riyaz; Tragante, Vinicius; Schmidt, Amand F; McCubrey, Raymond O; Holmes, Michael V; Howe, Laurence J; Direk, Kenan; Åkerblom, Axel; Leander, Karin; Virani, Salim S; Kaminski, Karol A; Muehlschlegel, Jochen D; Allayee, Hooman; Almgren, Peter; Alver, Maris; Baranova, Ekaterina V; Behlouli, Hassan; Boeckx, Bram; Braund, Peter S; Breitling, Lutz P; Delgado, Graciela; Duarte, Nubia E; Dubé, Marie-Pierre; Dufresne, Line; Eriksson, Niclas; Foco, Luisa; Scholz, Markus; Gijsberts, Crystel M; Glinge, Charlotte; Gong, Yan; Hartiala, Jaana; Heydarpour, Mahyar; Hubacek, Jaroslav A; Kleber, Marcus; Kofink, Daniel; Kotti, Salma; Kuukasjärvi, Pekka; Lee, Vei-Vei; Leiherer, Andreas; Lenzini, Petra A; Levin, Daniel; Lyytikäinen, Leo-Pekka; Martinelli, Nicola; Mons, Ute; Nelson, Christopher P; Nikus, Kjell; Pilbrow, Anna P; Ploski, Rafal; Sun, Yan V; Tanck, Michael W T; Tang, W H Wilson; Trompet, Stella; van der Laan, Sander W; Van Setten, Jessica; Vilmundarson, Ragnar O; Viviani Anselmi, Chiara; Vlachopoulou, Efthymia; Al Ali, Lawien; Boerwinkle, Eric; Briguori, Carlo; Carlquist, John F; Carruthers, Kathryn F; Casu, Gavino; Deanfield, John; Deloukas, Panos; Dudbridge, Frank; Engström, Thomas; Fitzpatrick, Natalie; Fox, Kim; Gigante, Bruna; James, Stefan; Lokki, Marja-Liisa; Lotufo, Paulo A; Marziliano, Nicola; Mordi, Ify R; Muhlestein, Joseph B; Newton-Cheh, Christopher; Pitha, Jan; Saely, Christoph H; Samman-Tahhan, Ayman; Sandesara, Pratik B; Teren, Andrej; Timmis, Adam; Van de Werf, Frans; Wauters, Els; Wilde, Arthur A M; Ford, Ian; Stott, David J; Algra, Ale; Andreassi, Maria G; Ardissino, Diego; Arsenault, Benoit J; Ballantyne, Christie M; Bergmeijer, Thomas O; Bezzina, Connie R; Body, Simon C; Boersma, Eric H; Bogaty, Peter; Bots, Michiel; Brenner, Hermann; Brugts, Jasper J; Burkhardt, Ralph; Carpeggiani, Clara; Condorelli, Gianluigi; Cooper-DeHoff, Rhonda M; Cresci, Sharon; Danchin, Nicolas; de Faire, Ulf; Doughty, Robert N; Drexel, Heinz; Engert, James C; Fox, Keith A A; Girelli, Domenico; Grobbee, Diederick E; Hagström, Emil; Hazen, Stanley L; Held, Claes; Hemingway, Harry; Hoefer, Imo E; Hovingh, G Kees; Jabbari, Reza; Johnson, Julie A; Jukema, J Wouter; Kaczor, Marcin P; Kähönen, Mika; Kettner, Jiri; Kiliszek, Marek; Klungel, Olaf H; Lagerqvist, Bo; Lambrechts, Diether; Laurikka, Jari O; Lehtimäki, Terho; Lindholm, Daniel; Mahmoodi, B K; Maitland-van der Zee, Anke H; McPherson, Ruth; Melander, Olle; Metspalu, Andres; Niemcunowicz-Janica, Anna; Olivieri, Oliviero; Opolski, Grzegorz; Palmer, Colin N; Pasterkamp, Gerard; Pepine, Carl J; Pereira, Alexandre C; Pilote, Louise; Quyyumi, Arshed A; Richards, A Mark; Sanak, Marek; Siegbahn, Agneta; Simon, Tabassome; Sinisalo, Juha; Smith, J Gustav; Spertus, John A; Stender, Steen; Stewart, Alexandre F R; Szczeklik, Wojciech; Szpakowicz, Anna; Tardif, Jean-Claude; Ten Berg, Jurriën M; Tfelt-Hansen, Jacob; Thanassoulis, George; Thiery, Joachim; Torp-Pedersen, Christian; van der Graaf, Yolanda; Visseren, Frank L J; Waltenberger, Johannes; Weeke, Peter E; Van der Harst, Pim; Lang, Chim C; Sattar, Naveed; Cameron, Vicky A; Anderson, Jeffrey L; Brophy, James M; Paré, Guillaume; Horne, Benjamin D; März, Winfried; Wallentin, Lars; Samani, Nilesh J; Hingorani, Aroon D; Asselbergs, Folkert W.
I: Circulation. Genomic and precision medicine, Bind 12, Nr. 4, e002470, 04.2019, s. 145-160.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - Subsequent Event Risk in Individuals with Established Coronary Heart Disease
T2 - Design and Rationale of the GENIUS-CHD Consortium
AU - Patel, Riyaz
AU - Tragante, Vinicius
AU - Schmidt, Amand F
AU - McCubrey, Raymond O
AU - Holmes, Michael V
AU - Howe, Laurence J
AU - Direk, Kenan
AU - Åkerblom, Axel
AU - Leander, Karin
AU - Virani, Salim S
AU - Kaminski, Karol A
AU - Muehlschlegel, Jochen D
AU - Allayee, Hooman
AU - Almgren, Peter
AU - Alver, Maris
AU - Baranova, Ekaterina V
AU - Behlouli, Hassan
AU - Boeckx, Bram
AU - Braund, Peter S
AU - Breitling, Lutz P
AU - Delgado, Graciela
AU - Duarte, Nubia E
AU - Dubé, Marie-Pierre
AU - Dufresne, Line
AU - Eriksson, Niclas
AU - Foco, Luisa
AU - Scholz, Markus
AU - Gijsberts, Crystel M
AU - Glinge, Charlotte
AU - Gong, Yan
AU - Hartiala, Jaana
AU - Heydarpour, Mahyar
AU - Hubacek, Jaroslav A
AU - Kleber, Marcus
AU - Kofink, Daniel
AU - Kotti, Salma
AU - Kuukasjärvi, Pekka
AU - Lee, Vei-Vei
AU - Leiherer, Andreas
AU - Lenzini, Petra A
AU - Levin, Daniel
AU - Lyytikäinen, Leo-Pekka
AU - Martinelli, Nicola
AU - Mons, Ute
AU - Nelson, Christopher P
AU - Nikus, Kjell
AU - Pilbrow, Anna P
AU - Ploski, Rafal
AU - Sun, Yan V
AU - Tanck, Michael W T
AU - Tang, W H Wilson
AU - Trompet, Stella
AU - van der Laan, Sander W
AU - Van Setten, Jessica
AU - Vilmundarson, Ragnar O
AU - Viviani Anselmi, Chiara
AU - Vlachopoulou, Efthymia
AU - Al Ali, Lawien
AU - Boerwinkle, Eric
AU - Briguori, Carlo
AU - Carlquist, John F
AU - Carruthers, Kathryn F
AU - Casu, Gavino
AU - Deanfield, John
AU - Deloukas, Panos
AU - Dudbridge, Frank
AU - Engström, Thomas
AU - Fitzpatrick, Natalie
AU - Fox, Kim
AU - Gigante, Bruna
AU - James, Stefan
AU - Lokki, Marja-Liisa
AU - Lotufo, Paulo A
AU - Marziliano, Nicola
AU - Mordi, Ify R
AU - Muhlestein, Joseph B
AU - Newton-Cheh, Christopher
AU - Pitha, Jan
AU - Saely, Christoph H
AU - Samman-Tahhan, Ayman
AU - Sandesara, Pratik B
AU - Teren, Andrej
AU - Timmis, Adam
AU - Van de Werf, Frans
AU - Wauters, Els
AU - Wilde, Arthur A M
AU - Ford, Ian
AU - Stott, David J
AU - Algra, Ale
AU - Andreassi, Maria G
AU - Ardissino, Diego
AU - Arsenault, Benoit J
AU - Ballantyne, Christie M
AU - Bergmeijer, Thomas O
AU - Bezzina, Connie R
AU - Body, Simon C
AU - Boersma, Eric H
AU - Bogaty, Peter
AU - Bots, Michiel
AU - Brenner, Hermann
AU - Brugts, Jasper J
AU - Burkhardt, Ralph
AU - Carpeggiani, Clara
AU - Condorelli, Gianluigi
AU - Cooper-DeHoff, Rhonda M
AU - Cresci, Sharon
AU - Danchin, Nicolas
AU - de Faire, Ulf
AU - Doughty, Robert N
AU - Drexel, Heinz
AU - Engert, James C
AU - Fox, Keith A A
AU - Girelli, Domenico
AU - Grobbee, Diederick E
AU - Hagström, Emil
AU - Hazen, Stanley L
AU - Held, Claes
AU - Hemingway, Harry
AU - Hoefer, Imo E
AU - Hovingh, G Kees
AU - Jabbari, Reza
AU - Johnson, Julie A
AU - Jukema, J Wouter
AU - Kaczor, Marcin P
AU - Kähönen, Mika
AU - Kettner, Jiri
AU - Kiliszek, Marek
AU - Klungel, Olaf H
AU - Lagerqvist, Bo
AU - Lambrechts, Diether
AU - Laurikka, Jari O
AU - Lehtimäki, Terho
AU - Lindholm, Daniel
AU - Mahmoodi, B K
AU - Maitland-van der Zee, Anke H
AU - McPherson, Ruth
AU - Melander, Olle
AU - Metspalu, Andres
AU - Niemcunowicz-Janica, Anna
AU - Olivieri, Oliviero
AU - Opolski, Grzegorz
AU - Palmer, Colin N
AU - Pasterkamp, Gerard
AU - Pepine, Carl J
AU - Pereira, Alexandre C
AU - Pilote, Louise
AU - Quyyumi, Arshed A
AU - Richards, A Mark
AU - Sanak, Marek
AU - Siegbahn, Agneta
AU - Simon, Tabassome
AU - Sinisalo, Juha
AU - Smith, J Gustav
AU - Spertus, John A
AU - Stender, Steen
AU - Stewart, Alexandre F R
AU - Szczeklik, Wojciech
AU - Szpakowicz, Anna
AU - Tardif, Jean-Claude
AU - Ten Berg, Jurriën M
AU - Tfelt-Hansen, Jacob
AU - Thanassoulis, George
AU - Thiery, Joachim
AU - Torp-Pedersen, Christian
AU - van der Graaf, Yolanda
AU - Visseren, Frank L J
AU - Waltenberger, Johannes
AU - Weeke, Peter E
AU - Van der Harst, Pim
AU - Lang, Chim C
AU - Sattar, Naveed
AU - Cameron, Vicky A
AU - Anderson, Jeffrey L
AU - Brophy, James M
AU - Paré, Guillaume
AU - Horne, Benjamin D
AU - März, Winfried
AU - Wallentin, Lars
AU - Samani, Nilesh J
AU - Hingorani, Aroon D
AU - Asselbergs, Folkert W
PY - 2019/4
Y1 - 2019/4
N2 - BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
AB - BACKGROUND: The "GENetIcs of sUbSequent Coronary Heart Disease" (GENIUS-CHD) consortium was established to facilitate discovery and validation of genetic variants and biomarkers for risk of subsequent CHD events, in individuals with established CHD.METHODS: The consortium currently includes 57 studies from 18 countries, recruiting 185,614 participants with either acute coronary syndrome, stable CHD or a mixture of both at baseline. All studies collected biological samples and followed-up study participants prospectively for subsequent events.RESULTS: Enrollment into the individual studies took place between 1985 to present day with duration of follow up ranging from 9 months to 15 years. Within each study, participants with CHD are predominantly of self-reported European descent (38%-100%), mostly male (44%-91%) with mean ages at recruitment ranging from 40 to 75 years. Initial feasibility analyses, using a federated analysis approach, yielded expected associations between age (HR 1.15 95% CI 1.14-1.16) per 5-year increase, male sex (HR 1.17, 95% CI 1.13-1.21) and smoking (HR 1.43, 95% CI 1.35-1.51) with risk of subsequent CHD death or myocardial infarction, and differing associations with other individual and composite cardiovascular endpoints.CONCLUSIONS: GENIUS-CHD is a global collaboration seeking to elucidate genetic and non-genetic determinants of subsequent event risk in individuals with established CHD, in order to improve residual risk prediction and identify novel drug targets for secondary prevention. Initial analyses demonstrate the feasibility and reliability of a federated analysis approach. The consortium now plans to initiate and test novel hypotheses as well as supporting replication and validation analyses for other investigators.
U2 - 10.1161/CIRCGEN.119.002470
DO - 10.1161/CIRCGEN.119.002470
M3 - Journal article
C2 - 30896328
VL - 12
SP - 145
EP - 160
JO - Circulation. Genomic and precision medicine
JF - Circulation. Genomic and precision medicine
SN - 2574-8300
IS - 4
M1 - e002470
ER -