1HMRI detection of gene expression in living cells by using protein tag and biotinylation probe

Akimasa Yoshimura; Shin Mizukami; Yuki Mori; Yoshichika Yoshioka; Kazuya Kikuchi

doi:10.1246/cl.130942

¹HMRI detection of gene expression in living cells by using protein tag and biotinylation probe

Akimasa Yoshimura, Shin Mizukami, Yuki Mori, Yoshichika Yoshioka, Kazuya Kikuchi^*

^*Corresponding author af dette arbejde

Center for Translational Neuromedicine

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

1 Citationer (Scopus)

Abstract

A new detection method for gene expression by magnetic resonance imaging (MRI) was developed using a proteinlabeling system based on a noncatalytic mutant β-lactamase (BL-tag system). By combining the BL-tag system with a specific biotinylation probe and a streptavidin-conjugated superparamagnetic iron oxide, target gene expression in living cells was successful detected by ¹HMRI.

Originalsprog	Engelsk
Tidsskrift	Chemistry Letters
Vol/bind	43
Udgave nummer	2
Sider (fra-til)	219-221
Antal sider	3
ISSN	0366-7022
DOI	https://doi.org/10.1246/cl.130942
Status	Udgivet - 2014

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10.1246/cl.130942

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Citationsformater

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abstract = "A new detection method for gene expression by magnetic resonance imaging (MRI) was developed using a proteinlabeling system based on a noncatalytic mutant β-lactamase (BL-tag system). By combining the BL-tag system with a specific biotinylation probe and a streptavidin-conjugated superparamagnetic iron oxide, target gene expression in living cells was successful detected by 1HMRI.",

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AU - Yoshimura, Akimasa

AU - Mizukami, Shin

AU - Mori, Yuki

AU - Yoshioka, Yoshichika

AU - Kikuchi, Kazuya

PY - 2014

Y1 - 2014

N2 - A new detection method for gene expression by magnetic resonance imaging (MRI) was developed using a proteinlabeling system based on a noncatalytic mutant β-lactamase (BL-tag system). By combining the BL-tag system with a specific biotinylation probe and a streptavidin-conjugated superparamagnetic iron oxide, target gene expression in living cells was successful detected by 1HMRI.

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U2 - 10.1246/cl.130942

DO - 10.1246/cl.130942

M3 - Journal article

AN - SCOPUS:84893510622

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VL - 43

SP - 219

EP - 221

JO - Chemistry Letters

JF - Chemistry Letters

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