@article{d6686bd0595611dd8d9f000ea68e967b,
title = "Suppression of tumor growth in vivo by local and systemic 90K level increase.",
abstract = "Expression levels of the immunostimulatory 90K antigen in mammary carcinoma, glioblastoma, and other tumor-derived cell lines inversely correlate with their tumorigenicity in athymic mice. Engineered enhancement of 90K expression results in significant (> 80%) tumor growth inhibition, not by direct action on the tumor cell, but by stimulation of the residual cell-mediated immune defense of the nude mouse. Enhanced 90K level effects are both localized and systemic and involve induction of ICAM-1 and VCAM-1 in the tumor endothelium. The findings presented suggest a role for 90K as a molecular alarm signal for the body's cellular defense against pathogens, which in a subset of tumors is suppressed to allow cancer progression.",
author = "B Jallal and J Powell and J Zachwieja and C Brakebusch and L Germain and J Jacobs and S Iacobelli and A Ullrich",
note = "Keywords: Animals; Antigens, Neoplasm; Carrier Proteins; Cell Adhesion Molecules; Cell Division; Glioblastoma; Glycoproteins; Humans; Immunity, Cellular; Intercellular Adhesion Molecule-1; Killer Cells, Lymphokine-Activated; Killer Cells, Natural; Lipoproteins; Mammary Neoplasms, Experimental; Mice; Mice, Nude; Neoplasm Proteins; Tumor Cells, Cultured; Tumor Markers, Biological; Vascular Cell Adhesion Molecule-1",
year = "1995",
language = "English",
volume = "55",
pages = "3223--7",
journal = "Cancer Research",
issn = "0008-5472",
publisher = "American Association for Cancer Research",
number = "15",
}