Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Scandinavian Journal of Immunology |
Vol/bind | 64 |
Udgave nummer | 6 |
Sider (fra-til) | 633-638 |
Antal sider | 5 |
ISSN | 0300-9475 |
DOI | |
Status | Udgivet - 2006 |
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Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice. / Sorensen, G.L.; Hjelmborg, J.V.B.; Leth-Larsen, R.; Schmidt, V.; Fenger, Mogens; Poulain, F.; Hawgood, S.; Sørensen, Thorkild I.A.; Kyvik, K.O.; Holmskov, U.
I: Scandinavian Journal of Immunology, Bind 64, Nr. 6, 2006, s. 633-638.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Surfactant protein D of the innate immune defence is inversely associated with human obesity and SP-D deficiency infers increased body weight in mice
AU - Sorensen, G.L.
AU - Hjelmborg, J.V.B.
AU - Leth-Larsen, R.
AU - Schmidt, V.
AU - Fenger, Mogens
AU - Poulain, F.
AU - Hawgood, S.
AU - Sørensen, Thorkild I.A.
AU - Kyvik, K.O.
AU - Holmskov, U.
PY - 2006
Y1 - 2006
N2 - Surfactant protein D (SP-D) is a key regulator of pathogen-induced inflammation. SP-D is further involved in lipid homeostasis in mouse lung and circulation and recent data have demonstrated that the body mass index (BMI; in kg/m(2)) is influenced by genes in common with SP-D. The objective of the present study was to describe the association between serum SP-D and weight, waist circumference or BMI, and furthermore to observe body weight development in SP-D-deficient (Spd-/-) mice. As a part of the Danish population-based twin study (GEMINAKAR) on the metabolic syndrome, we analysed 1476 Danish twins for serum SP-D and investigated associations with weight, waist circumference and BMI by multiple regression analysis. Serum SP-D was significantly and inversely associated with weight (P = 0.001) and waist circumference in men (P < 0.001) and to BMI in both genders (P = 0.039 women, P < 0.001 men). The age-dependent increase in serum SP-D was most prominent in lean persons (BMI < 20). Spd-/- mice and wild-type mice were subjected to a feeding study and body weights were recorded in a time course over 24 weeks. Spd-/- mouse weight gain was significantly increased, with 90 mg/week (P < 0.0001) in males on normal chow. Fat percentage was significantly increased by 17% in the Spd-/- male mice (P = 0.003). We conclude, that there is an association between low levels or absent SP-D and obesity.
AB - Surfactant protein D (SP-D) is a key regulator of pathogen-induced inflammation. SP-D is further involved in lipid homeostasis in mouse lung and circulation and recent data have demonstrated that the body mass index (BMI; in kg/m(2)) is influenced by genes in common with SP-D. The objective of the present study was to describe the association between serum SP-D and weight, waist circumference or BMI, and furthermore to observe body weight development in SP-D-deficient (Spd-/-) mice. As a part of the Danish population-based twin study (GEMINAKAR) on the metabolic syndrome, we analysed 1476 Danish twins for serum SP-D and investigated associations with weight, waist circumference and BMI by multiple regression analysis. Serum SP-D was significantly and inversely associated with weight (P = 0.001) and waist circumference in men (P < 0.001) and to BMI in both genders (P = 0.039 women, P < 0.001 men). The age-dependent increase in serum SP-D was most prominent in lean persons (BMI < 20). Spd-/- mice and wild-type mice were subjected to a feeding study and body weights were recorded in a time course over 24 weeks. Spd-/- mouse weight gain was significantly increased, with 90 mg/week (P < 0.0001) in males on normal chow. Fat percentage was significantly increased by 17% in the Spd-/- male mice (P = 0.003). We conclude, that there is an association between low levels or absent SP-D and obesity.
U2 - 10.1111/j.1365-3083.2006.01853.x
DO - 10.1111/j.1365-3083.2006.01853.x
M3 - Journal article
C2 - 17083619
VL - 64
SP - 633
EP - 638
JO - Scandinavian Journal of Immunology, Supplement
JF - Scandinavian Journal of Immunology, Supplement
SN - 0301-6323
IS - 6
ER -