@article{c96ad7b0702b11dd8d9f000ea68e967b,
title = "Sustained systemic delivery of monoclonal antibodies by genetically modified skin fibroblasts.",
abstract = "In vivo production and systemic delivery of therapeutic antibodies by engineered cells might advantageously replace injection of purified antibodies for treating a variety of life-threatening diseases, including cancer, acquired immunodeficiency syndrome, and autoimmune diseases. We report here that skin fibroblasts retrovirally transduced to express immunoglobulin genes can be used for sustained long-term systemic delivery of cloned antibodies in immunocompetent mice. Importantly, no anti- idiotypic response against the ectopically expressed model antibody used in this study was observed. This supports the notion that skin fibroblasts can potentially be used in antibody-based gene/cell therapy protocols without inducing any adverse immune response in treated individuals.",
author = "D No{\"e}l and M Pelegrin and F Brockly and Lund, {Anders Henrik} and M Piechaczyk",
note = "Keywords: Animals; Antibodies, Monoclonal; Antibody Formation; Disease Models, Animal; Fibroblasts; Gene Therapy; Humans; Immunocompetence; Mice; Skin",
year = "2000",
doi = "10.1046/j.1523-1747.2000.00106.x",
language = "English",
volume = "115",
pages = "740--5",
journal = "Journal of Investigative Dermatology",
issn = "0022-202X",
publisher = "nature publishing group",
number = "4",
}