@article{9de2daa0596211dd8d9f000ea68e967b,
title = "Syndecans-2 and -4; close cousins, but not identical twins.",
abstract = "The vertebrate syndecans, which make up a four-member family of small type I transmembrane heparan sulfate proteoglycans, constitute evolutionarily conserved family proteins. In particular, sequences in the transmembrane and cytoplasmic domains are a unifying feature within the family. However, the extracellular domain sequences are molecule-specific, implying that different syndecans have evolved to carry out similar, but non-identical, functions. While all four syndecans have been implicated in regulation of the cytoskeleton, their roles are clearly complex. Recent developments indicate that the closely related syndecan-2 and -4 have separable functions, though both bind a number of ligands through their heparan sulfate chains. The specification of these activities is probably core protein related, but is it due to a distinct expression pattern or molecule-specific regulatory mechanisms? Although there is not yet enough data to provide unambiguous answers, here we shall review the known functions and regulatory mechanisms of syndecan-2 and -4.",
author = "Eok-Soo Oh and Couchman, {John R}",
note = "Keywords: Animals; Cell Adhesion; Cell Division; Cytoskeleton; Growth Substances; Humans; Membrane Glycoproteins; Neovascularization, Physiologic; Protein Conformation; Proteoglycans; Syndecan-2; Syndecan-4; Tissue Distribution",
year = "2004",
language = "English",
volume = "17",
pages = "181--7",
journal = "Molecules and Cells",
issn = "1016-8478",
publisher = "Korean Society for Molecular Biology",
number = "2",
}