Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

Søren Wedel Svenningsen; Rikki Franklin Frederiksen; Claire Counil; Mario Ficker; Jørgen J. Leisner; Jørn Bolstad Christensen

doi:10.3390/molecules25061389

Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

Søren Wedel Svenningsen, Rikki Franklin Frederiksen, Claire Counil, Mario Ficker, Jørgen J. Leisner, Jørn Bolstad Christensen^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

20 Citationer (Scopus)

117 Downloads (Pure)

Abstract

Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.

Originalsprog	Engelsk
Artikelnummer	1389
Tidsskrift	Molecules
Vol/bind	25
Udgave nummer	6
Sider (fra-til)	1-13
ISSN	1420-3049
DOI	https://doi.org/10.3390/molecules25061389
Status	Udgivet - 2020

Adgang til dokumentet

10.3390/molecules25061389Licens: CC BY

molecules-25-01389-v2Forlagets udgivne version, 975 KBLicens: CC BY

Citationsformater

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abstract = "Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.",

keywords = "Antimicrobial compounds, Ciprofloxacin, Dendrimers",

author = "Svenningsen, {S{\o}ren Wedel} and Frederiksen, {Rikki Franklin} and Claire Counil and Mario Ficker and Leisner, {J{\o}rgen J.} and Christensen, {J{\o}rn Bolstad}",

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T1 - Synthesis and Antimicrobial Properties of a Ciprofloxacin and PAMAM-dendrimer Conjugate

AU - Svenningsen, Søren Wedel

AU - Frederiksen, Rikki Franklin

AU - Counil, Claire

AU - Ficker, Mario

AU - Leisner, Jørgen J.

AU - Christensen, Jørn Bolstad

PY - 2020

Y1 - 2020

N2 - Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.

AB - Infections caused by bacteria resistant to antibiotics are an increasing problem. Multivalent antibiotics could be a solution. In the present study, a covalent conjugate between Ciprofloxacin and a G0-PAMAM dendrimer has been synthesized and tested against clinically relevant Gram-positive and Gram-negative bacteria. The conjugate has antimicrobial activity and there is a positive dendritic effect compared to Ciprofloxacin itself.

KW - Antimicrobial compounds

KW - Ciprofloxacin

KW - Dendrimers

U2 - 10.3390/molecules25061389

DO - 10.3390/molecules25061389

M3 - Journal article

C2 - 32197523

AN - SCOPUS:85082058612

VL - 25

SP - 1

EP - 13

JO - Molecules

JF - Molecules

SN - 1420-3049

IS - 6

M1 - 1389

ER -