Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

Elton L. Borges; Marta T. Ignasiak; Yuliia Velichenko; Gelson Perin; Craig A. Hutton; Michael J. Davies; Carl H. Schiesser

doi:10.1039/c8cc00565f

Synthesis and antioxidant capacity of novel stable 5-tellurofuranose derivatives

Elton L. Borges, Marta T. Ignasiak, Yuliia Velichenko, Gelson Perin, Craig A. Hutton, Michael J. Davies, Carl H. Schiesser

Inflammation, Metabolism and Oxidation

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

15 Citationer (Scopus)

Abstract

Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

Originalsprog	Engelsk
Tidsskrift	Chemical Communications
Vol/bind	54
Udgave nummer	24
Sider (fra-til)	2990-2993
ISSN	1359-7345
DOI	https://doi.org/10.1039/c8cc00565f
Status	Udgivet - 25 mar. 2018

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Citationsformater

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abstract = "Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.",

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AU - Borges, Elton L.

AU - Ignasiak, Marta T.

AU - Velichenko, Yuliia

AU - Perin, Gelson

AU - Hutton, Craig A.

AU - Davies, Michael J.

AU - Schiesser, Carl H.

PY - 2018/3/25

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AB - Novel stable tellurium-containing carbohydrate derivatives are prepared from hexitols and pentitols through a double nucleophilic substitution with NaHTe in PEG-400. These tellurosugars react at very high rates with two-electron oxidants, including hypochlorous and peroxynitrous acid, formed at sites of inflammation, and show considerable promise as protective agents against oxidative damage.

U2 - 10.1039/c8cc00565f

DO - 10.1039/c8cc00565f

M3 - Journal article

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SN - 1359-7345

VL - 54

SP - 2990

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JO - Chemical Communications

JF - Chemical Communications

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