Synthesis of new isoxazoline-based acidic amino acids and investigation of their affinity and selectivity profile at ionotropic glutamate receptors

Andrea Pinto, Paola Conti, Giovanni Grazioso, Lucia Tamborini, Ulf Madsen, Birgitte Nielsen, Carlo De Micheli

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    Abstract

    The synthesis of four new isoxazoline-based amino acids being analogues of previously described glutamate receptor ligands is reported and their affinity for ionotropic glutamate receptors is analyzed in comparison with that of selected model compounds. Molecular modelling investigations have been carried out to rationalize the interaction with the NMDA receptors.
    OriginalsprogEngelsk
    TidsskriftEuropean Journal of Medicinal Chemistry
    Vol/bind46
    Udgave nummer2
    Sider (fra-til)787-793
    ISSN0223-5234
    DOI
    StatusUdgivet - 1 feb. 2011

    Bibliografisk note

    Keywords: glutamic acid, ionotropic Glu receptors, isoxazoline, 1,3-dipolar cycloaddition

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    • Det tidligere Farmaceutiske Fakultet

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