Synthesis of the thapsigargins

Steven V. Ley; Alessandra Antonello; Emily P. Balskus; David T. Booth; Søren B. Christensen; Ed Cleator; Helen Gold; Klemens Högenauer; Udo Hünger; Rebecca M. Myers; Steven F. Oliver; Oliver Simic; Martin D. Smith; Helmer Søhoel; Alison J.A. Woolford

doi:10.1073/pnas.0403300101

Synthesis of the thapsigargins

Steven V. Ley^*, Alessandra Antonello, Emily P. Balskus, David T. Booth, Søren B. Christensen, Ed Cleator, Helen Gold, Klemens Högenauer, Udo Hünger, Rebecca M. Myers, Steven F. Oliver, Oliver Simic, Martin D. Smith, Helmer Søhoel, Alison J.A. Woolford

^*Corresponding author af dette arbejde

LUKKET: Natural Products and Peptides

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

71 Citationer (Scopus)

Abstract

The thapsigargins are a family of complex guaianolides with potent and selective Ca²⁺-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.

Originalsprog	Engelsk
Tidsskrift	Proceedings of the National Academy of Sciences of the United States of America
Vol/bind	101
Udgave nummer	33
Sider (fra-til)	12073-12078
Antal sider	6
ISSN	0027-8424
DOI	https://doi.org/10.1073/pnas.0403300101
Status	Udgivet - 17 aug. 2004

Adgang til dokumentet

10.1073/pnas.0403300101

Andre filer og links

Link to publication in Scopus

Citationsformater

Ley, S. V., Antonello, A., Balskus, E. P., Booth, D. T., Christensen, S. B., Cleator, E., Gold, H., Högenauer, K., Hünger, U., Myers, R. M., Oliver, S. F., Simic, O., Smith, M. D., Søhoel, H., & Woolford, A. J. A. (2004). Synthesis of the thapsigargins. Proceedings of the National Academy of Sciences of the United States of America, 101(33), 12073-12078. https://doi.org/10.1073/pnas.0403300101

Synthesis of the thapsigargins. / Ley, Steven V.; Antonello, Alessandra; Balskus, Emily P.; Booth, David T.; Christensen, Søren B.; Cleator, Ed; Gold, Helen; Högenauer, Klemens; Hünger, Udo; Myers, Rebecca M.; Oliver, Steven F.; Simic, Oliver; Smith, Martin D.; Søhoel, Helmer; Woolford, Alison J.A.

I: Proceedings of the National Academy of Sciences of the United States of America, Bind 101, Nr. 33, 17.08.2004, s. 12073-12078.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ley, SV, Antonello, A, Balskus, EP, Booth, DT, Christensen, SB, Cleator, E, Gold, H, Högenauer, K, Hünger, U, Myers, RM, Oliver, SF, Simic, O, Smith, MD, Søhoel, H & Woolford, AJA 2004, 'Synthesis of the thapsigargins', Proceedings of the National Academy of Sciences of the United States of America, bind 101, nr. 33, s. 12073-12078. https://doi.org/10.1073/pnas.0403300101

Ley, Steven V. ; Antonello, Alessandra ; Balskus, Emily P. ; Booth, David T. ; Christensen, Søren B. ; Cleator, Ed ; Gold, Helen ; Högenauer, Klemens ; Hünger, Udo ; Myers, Rebecca M. ; Oliver, Steven F. ; Simic, Oliver ; Smith, Martin D. ; Søhoel, Helmer ; Woolford, Alison J.A. / Synthesis of the thapsigargins. I: Proceedings of the National Academy of Sciences of the United States of America. 2004 ; Bind 101, Nr. 33. s. 12073-12078.

@article{fdb0f576692d483d8546e9a70cd398d7,

title = "Synthesis of the thapsigargins",

abstract = "The thapsigargins are a family of complex guaianolides with potent and selective Ca2+-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.",

author = "Ley, {Steven V.} and Alessandra Antonello and Balskus, {Emily P.} and Booth, {David T.} and Christensen, {S{\o}ren B.} and Ed Cleator and Helen Gold and Klemens H{\"o}genauer and Udo H{\"u}nger and Myers, {Rebecca M.} and Oliver, {Steven F.} and Oliver Simic and Smith, {Martin D.} and Helmer S{\o}hoel and Woolford, {Alison J.A.}",

year = "2004",

month = aug,

day = "17",

doi = "10.1073/pnas.0403300101",

language = "English",

volume = "101",

pages = "12073--12078",

journal = "Proceedings of the National Academy of Sciences of the United States of America",

issn = "0027-8424",

publisher = "The National Academy of Sciences of the United States of America",

number = "33",

}

TY - JOUR

T1 - Synthesis of the thapsigargins

AU - Ley, Steven V.

AU - Antonello, Alessandra

AU - Balskus, Emily P.

AU - Booth, David T.

AU - Christensen, Søren B.

AU - Cleator, Ed

AU - Gold, Helen

AU - Högenauer, Klemens

AU - Hünger, Udo

AU - Myers, Rebecca M.

AU - Oliver, Steven F.

AU - Simic, Oliver

AU - Smith, Martin D.

AU - Søhoel, Helmer

AU - Woolford, Alison J.A.

PY - 2004/8/17

Y1 - 2004/8/17

N2 - The thapsigargins are a family of complex guaianolides with potent and selective Ca2+-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.

AB - The thapsigargins are a family of complex guaianolides with potent and selective Ca2+-modulating properties. This article documents the evolution of a synthetic route through several iterations to a final practical and scaleable synthetic route capable of generating both unnatural and natural products based around the guaianolide skeleton.

UR - http://www.scopus.com/inward/record.url?scp=4344649579&partnerID=8YFLogxK

U2 - 10.1073/pnas.0403300101

DO - 10.1073/pnas.0403300101

M3 - Journal article

C2 - 15226504

AN - SCOPUS:4344649579

VL - 101

SP - 12073

EP - 12078

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 33

ER -