Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Katja E Grier, Anders H Hansen, Christina S. Haxvig, Xin Li, Oliver Krigslund, Niels Behrendt, Lars H Engelholm, Fabio Rossi, Bebiana C Sousa, Grant J Harradence, Nicolas Camper, Katrine M. Qvortrup

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

4 Citationer (Scopus)

Abstract

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

OriginalsprogEngelsk
TidsskriftChemical Communications
Vol/bind59
Udgave nummer47
Sider (fra-til)7240-7242
ISSN1359-7345
DOI
StatusUdgivet - 2023

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