Abstract
We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.
Originalsprog | Engelsk |
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Tidsskrift | Chemical Communications |
Vol/bind | 59 |
Udgave nummer | 47 |
Sider (fra-til) | 7240-7242 |
ISSN | 1359-7345 |
DOI | |
Status | Udgivet - 2023 |