Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Katja E Grier; Anders H Hansen; Christina S. Haxvig; Xin Li; Oliver Krigslund; Niels Behrendt; Lars H Engelholm; Fabio Rossi; Bebiana C Sousa; Grant J Harradence; Nicolas Camper; Katrine M. Qvortrup

doi:10.1039/d3cc01596c

Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

Katja E Grier, Anders H Hansen, Christina S. Haxvig, Xin Li, Oliver Krigslund, Niels Behrendt, Lars H Engelholm, Fabio Rossi, Bebiana C Sousa, Grant J Harradence, Nicolas Camper, Katrine M. Qvortrup

Sørensen Group

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

Abstract

We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

Originalsprog	Engelsk
Tidsskrift	Chemical Communications
Vol/bind	59
Udgave nummer	47
Sider (fra-til)	7240-7242
ISSN	1359-7345
DOI	https://doi.org/10.1039/d3cc01596c
Status	Udgivet - 2023

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10.1039/d3cc01596c

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Citationsformater

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title = "Targeted delivery of alcohol-containing payloads with antibody-drug conjugates",

abstract = "We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines. ",

author = "Grier, {Katja E} and Hansen, {Anders H} and Haxvig, {Christina S.} and Xin Li and Oliver Krigslund and Niels Behrendt and Engelholm, {Lars H} and Fabio Rossi and Sousa, {Bebiana C} and Harradence, {Grant J} and Nicolas Camper and Qvortrup, {Katrine M.}",

year = "2023",

doi = "10.1039/d3cc01596c",

language = "English",

volume = "59",

pages = "7240--7242",

journal = "Chemical Communications",

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publisher = "Royal Society of Chemistry",

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TY - JOUR

T1 - Targeted delivery of alcohol-containing payloads with antibody-drug conjugates

AU - Grier, Katja E

AU - Hansen, Anders H

AU - Haxvig, Christina S.

AU - Li, Xin

AU - Krigslund, Oliver

AU - Behrendt, Niels

AU - Engelholm, Lars H

AU - Rossi, Fabio

AU - Sousa, Bebiana C

AU - Harradence, Grant J

AU - Camper, Nicolas

AU - Qvortrup, Katrine M.

PY - 2023

Y1 - 2023

N2 - We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

AB - We herein describe the cell-specific release of alcohol-containing payloads via a sulfatase-sensitive linker in antibody-drug conjugates (ADCs). The linker shows efficient sulfatase-mediated release and high stability in human and mouse plasma. In vitro evaluation demonstrates potent antigen dependent toxicity towards breast cancer cell lines.

U2 - 10.1039/d3cc01596c

DO - 10.1039/d3cc01596c

M3 - Journal article

C2 - 37222285

SN - 1359-7345

VL - 59

SP - 7240

EP - 7242

JO - Chemical Communications

JF - Chemical Communications

IS - 47

ER -