Abstract
Stem cell transplantation procedures using intraparenchymal injections cause tissue injury in addition to associated surgical risks. Intra-venous cell administration give engraftment in parenchymal lesions although the method has low efficacy and specificity. In pathological conditions with inflammation, such as traumatic brain injury, there is a transient up-regulation of ICAM-1 and VCAM-1 which might provide enviromental cues for migration of stem cells from blood to parenchyma. The aim of this study was to i) analyze the effect of intra-arterial administration on cellular engraftment, ii) compare engraftment and side effects between three different stem cell systems and iii) analyze gene expression in these three systems.
Originalsprog | Engelsk |
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Tidsskrift | Cell Transplantation |
ISSN | 0963-6897 |
DOI | |
Status | Udgivet - 7 jun. 2011 |