Telomere dynamics as mediators of gut microbiota–host interactions

Michael L. Pepke; Søren B. Hansen; Morten T. Limborg

doi:10.1016/j.tcb.2024.08.003

Telomere dynamics as mediators of gut microbiota–host interactions

Michael L. Pepke^*, Søren B. Hansen, Morten T. Limborg

^*Corresponding author af dette arbejde

Section for Hologenomics

Publikation: Bidrag til tidsskrift › Letter › peer review

1 Citationer (Scopus)

Abstract

The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.

Originalsprog	Engelsk
Tidsskrift	Trends in Cell Biology
Vol/bind	34
Udgave nummer	10
Sider (fra-til)	805-808
Antal sider	4
ISSN	0962-8924
DOI	https://doi.org/10.1016/j.tcb.2024.08.003
Status	Udgivet - 2024

Bibliografisk note

Funding Information:
We apologize to authors whose work could not be included due to space limitations. This study was funded by The Danish National Research Foundation ( CEH - DNRF143 ) and a Carlsberg Foundation award to M.T.L. ( CF21-0356 ).

Publisher Copyright:
© 2024 Elsevier Ltd

Adgang til dokumentet

10.1016/j.tcb.2024.08.003

Citationsformater

@article{0129c301162a40aea354bd266341e0c2,

title = "Telomere dynamics as mediators of gut microbiota–host interactions",

abstract = "The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.",

keywords = "gut barrier, holobiont, microbiome, senescence, telomerase, telomere length",

author = "Pepke, {Michael L.} and Hansen, {S{\o}ren B.} and Limborg, {Morten T.}",

note = "Publisher Copyright: {\textcopyright} 2024 Elsevier Ltd",

year = "2024",

doi = "10.1016/j.tcb.2024.08.003",

language = "English",

volume = "34",

pages = "805--808",

journal = "Trends in Cell Biology",

issn = "0962-8924",

publisher = "Elsevier Ltd. * Trends Journals",

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TY - JOUR

T1 - Telomere dynamics as mediators of gut microbiota–host interactions

AU - Pepke, Michael L.

AU - Hansen, Søren B.

AU - Limborg, Morten T.

PY - 2024

Y1 - 2024

N2 - The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.

AB - The highly proliferative gut tissue exhibits rapid telomere shortening with systemic effects on the host organism. Recent studies have demonstrated a bidirectionality in interactions between intestinal telomere length dynamics and the composition and activity of the gut microbiome thus linking processes of inflammation, dysbiosis and aging across different vertebrate species.

KW - gut barrier

KW - holobiont

KW - microbiome

KW - senescence

KW - telomerase

KW - telomere length

U2 - 10.1016/j.tcb.2024.08.003

DO - 10.1016/j.tcb.2024.08.003

M3 - Letter

C2 - 39256139

AN - SCOPUS:85203444603

SN - 0962-8924

VL - 34

SP - 805

EP - 808

JO - Trends in Cell Biology

JF - Trends in Cell Biology

IS - 10

ER -