The cardioprotective effect of brief acidic reperfusion after ischemia in perfused rat hearts is not mimicked by inhibition of the Na+/H+ exchanger NHE1

Ann-Dorit Andersen, Bo Hjorth Bentzen, H. Salling, Henrik Klingberg, Morten Kanneworff, Morten Grunnet, Stine Helene Falsig Pedersen

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

8 Citationer (Scopus)

Abstract

Ischemic postconditioning (PostC), i.e. brief ischemia-reperfusion cycles before full reperfusion, is protective against cardiac ischemia/reperfusion (I/R) injury. Inhibition of the Na(+)/H(+) exchanger NHE1 and delayed intracellular pH-normalization have been proposed to underlie protection by PostC.
OriginalsprogEngelsk
TidsskriftCellular Physiology and Biochemistry
Vol/bind28
Udgave nummer1
Sider (fra-til)13-24
Antal sider12
ISSN1015-8987
DOI
StatusUdgivet - 2011

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