Abstract
Originalsprog | Engelsk |
---|---|
Tidsskrift | Twin Research and Human Genetics |
Vol/bind | 18 |
Udgave nummer | 4 |
Sider (fra-til) | 348-60 |
Antal sider | 13 |
ISSN | 1832-4274 |
DOI | |
Status | Udgivet - aug. 2015 |
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I: Twin Research and Human Genetics, Bind 18, Nr. 4, 08.2015, s. 348-60.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - The CODATwins Project
T2 - The Cohort Description of Collaborative Project of Development of Anthropometrical Measures in Twins to Study Macro-Environmental Variation in Genetic and Environmental Effects on Anthropometric Traits
AU - Silventoinen, Karri
AU - Jelenkovic, Aline
AU - Sund, Reijo
AU - Honda, Chika
AU - Aaltonen, Sari
AU - Yokoyama, Yoshie
AU - Tarnoki, Adam D
AU - Tarnoki, David L
AU - Ning, Feng
AU - Ji, Fuling
AU - Pang, Zengchang
AU - Ordoñana, Juan R
AU - Sánchez-Romera, Juan F
AU - Colodro-Conde, Lucia
AU - Burt, S Alexandra
AU - Klump, Kelly L
AU - Medland, Sarah E
AU - Montgomery, Grant W
AU - Kandler, Christian
AU - McAdams, Tom A
AU - Eley, Thalia C
AU - Gregory, Alice M
AU - Saudino, Kimberly J
AU - Dubois, Lise
AU - Boivin, Michel
AU - Haworth, Claire M A
AU - Plomin, Robert
AU - Öncel, Sevgi Y
AU - Aliev, Fazil
AU - Stazi, Maria A
AU - Fagnani, Corrado
AU - D'Ippolito, Cristina
AU - Craig, Jeffrey M
AU - Saffery, Richard
AU - Siribaddana, Sisira H
AU - Hotopf, Matthew
AU - Sumathipala, Athula
AU - Spector, Timothy
AU - Mangino, Massimo
AU - Lachance, Genevieve
AU - Gatz, Margaret
AU - Butler, David A
AU - Bayasgalan, Gombojav
AU - Narandalai, Danshiitsoodol
AU - Freitas, Duarte L
AU - Maia, José Antonio
AU - Harden, K Paige
AU - Tucker-Drob, Elliot M
AU - Christensen, Kaare
AU - Skytthe, Axel
AU - Kyvik, Kirsten O
AU - Hong, Changhee
AU - Chong, Youngsook
AU - Derom, Catherine A
AU - Vlietinck, Robert F
AU - Loos, Ruth J F
AU - Cozen, Wendy
AU - Hwang, Amie E
AU - Mack, Thomas M
AU - He, Mingguang
AU - Ding, Xiaohu
AU - Chang, Billy
AU - Silberg, Judy L
AU - Eaves, Lindon J
AU - Maes, Hermine H
AU - Cutler, Tessa L
AU - Hopper, John L
AU - Aujard, Kelly
AU - Magnusson, Patrik K E
AU - Pedersen, Nancy L
AU - Aslan, Anna K Dahl
AU - Song, Yun-Mi
AU - Yang, Sarah
AU - Lee, Kayoung
AU - Baker, Laura A
AU - Tuvblad, Catherine
AU - Bjerregaard-Andersen, Morten
AU - Beck-Nielsen, Henning
AU - Sodemann, Morten
AU - Heikkilä, Kauko
AU - Tan, Qihua
AU - Zhang, Dongfeng
AU - Swan, Gary E
AU - Krasnow, Ruth
AU - Jang, Kerry L
AU - Knafo-Noam, Ariel
AU - Mankuta, David
AU - Abramson, Lior
AU - Lichtenstein, Paul
AU - Krueger, Robert F
AU - McGue, Matt
AU - Pahlen, Shandell
AU - Tynelius, Per
AU - Duncan, Glen E
AU - Buchwald, Dedra
AU - Corley, Robin P
AU - Huibregtse, Brooke M
AU - Nelson, Tracy L
AU - Whitfield, Keith E
AU - Franz, Carol E
AU - Kremen, William S
AU - Lyons, Michael J
AU - Ooki, Syuichi
AU - Brandt, Ingunn
AU - Nilsen, Thomas Sevenius
AU - Inui, Fujio
AU - Watanabe, Mikio
AU - Bartels, Meike
AU - van Beijsterveldt, Toos C E M
AU - Wardle, Jane
AU - Llewellyn, Clare H
AU - Fisher, Abigail
AU - Rebato, Esther
AU - Martin, Nicholas G
AU - Iwatani, Yoshinori
AU - Hayakawa, Kazuo
AU - Rasmussen, Finn
AU - Sung, Joohon
AU - Harris, Jennifer R
AU - Willemsen, Gonneke
AU - Busjahn, Andreas
AU - Goldberg, Jack H
AU - Boomsma, Dorret I
AU - Hur, Yoon-Mi
AU - Sørensen, Thorkild I A
AU - Kaprio, Jaakko
PY - 2015/8
Y1 - 2015/8
N2 - For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
AB - For over 100 years, the genetics of human anthropometric traits has attracted scientific interest. In particular, height and body mass index (BMI, calculated as kg/m2) have been under intensive genetic research. However, it is still largely unknown whether and how heritability estimates vary between human populations. Opportunities to address this question have increased recently because of the establishment of many new twin cohorts and the increasing accumulation of data in established twin cohorts. We started a new research project to analyze systematically (1) the variation of heritability estimates of height, BMI and their trajectories over the life course between birth cohorts, ethnicities and countries, and (2) to study the effects of birth-related factors, education and smoking on these anthropometric traits and whether these effects vary between twin cohorts. We identified 67 twin projects, including both monozygotic (MZ) and dizygotic (DZ) twins, using various sources. We asked for individual level data on height and weight including repeated measurements, birth related traits, background variables, education and smoking. By the end of 2014, 48 projects participated. Together, we have 893,458 height and weight measures (52% females) from 434,723 twin individuals, including 201,192 complete twin pairs (40% monozygotic, 40% same-sex dizygotic and 20% opposite-sex dizygotic) representing 22 countries. This project demonstrates that large-scale international twin studies are feasible and can promote the use of existing data for novel research purposes.
KW - Anthropometry
KW - Body Height
KW - Body Mass Index
KW - Body Weight
KW - Female
KW - Gene-Environment Interaction
KW - Humans
KW - Male
KW - Phenotype
KW - Twin Studies as Topic
KW - Twins
U2 - 10.1017/thg.2015.29
DO - 10.1017/thg.2015.29
M3 - Journal article
C2 - 26014041
SN - 1832-4274
VL - 18
SP - 348
EP - 360
JO - Twin Research and Human Genetics
JF - Twin Research and Human Genetics
IS - 4
ER -