The Danish PET/depression project: cognitive function and regional cerebral blood flow.

B Ravnkilde; P Videbech; K Clemmensen; A Egander; N A Rasmussen; A Gjedde; R Rosenberg; A Gade

The Danish PET/depression project: cognitive function and regional cerebral blood flow.

B Ravnkilde, P Videbech, K Clemmensen, A Egander, N A Rasmussen, A Gjedde, R Rosenberg, A Gade

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

11 Citationer (Scopus)

Abstract

Udgivelsesdato: 2003-Jul

Originalsprog	Engelsk
Tidsskrift	Acta Psychiatrica Scandinavica
Vol/bind	108
Udgave nummer	1
Sider (fra-til)	32-40
Antal sider	8
ISSN	0001-690X
Status	Udgivet - 2003
Udgivet eksternt	Ja

Citationsformater

@article{39ec0db0b31511debc73000ea68e967b,

title = "The Danish PET/depression project: cognitive function and regional cerebral blood flow.",

abstract = "OBJECTIVE: To clarify the relationship between cognitive functions and regional cerebral blood flow (rCBF) in a large group of depressed patients compared with healthy controls. METHOD: A set of principal components was extracted from scores of a battery of neuropsychological tests of 40 patients suffering from major depression and 49 healthy controls. The components were correlated by multiple linear regression analyses to selected regions of interest in the brain obtained from positron emission tomography images. RESULTS: In contrast to findings in the healthy controls, cognitive functions in the depressed patients correlated significantly with rCBF in specified regions of interest in only a few instances. CONCLUSION: Our study indicates that disturbed cognitive functions in depression do not relate to specific areas of the brain in the same way as normal cognitive functioning, suggesting that the abnormalities of brain function in major depression may be qualitative, rather than quantitative, in nature.",

author = "B Ravnkilde and P Videbech and K Clemmensen and A Egander and Rasmussen, {N A} and A Gjedde and R Rosenberg and A Gade",

year = "2003",

language = "English",

volume = "108",

pages = "32--40",

journal = "Acta Psychiatrica Scandinavica",

issn = "0001-690X",

publisher = "Wiley",

number = "1",

}

TY - JOUR

T1 - The Danish PET/depression project: cognitive function and regional cerebral blood flow.

AU - Ravnkilde, B

AU - Videbech, P

AU - Clemmensen, K

AU - Egander, A

AU - Rasmussen, N A

AU - Gjedde, A

AU - Rosenberg, R

AU - Gade, A

PY - 2003

Y1 - 2003

N2 - OBJECTIVE: To clarify the relationship between cognitive functions and regional cerebral blood flow (rCBF) in a large group of depressed patients compared with healthy controls. METHOD: A set of principal components was extracted from scores of a battery of neuropsychological tests of 40 patients suffering from major depression and 49 healthy controls. The components were correlated by multiple linear regression analyses to selected regions of interest in the brain obtained from positron emission tomography images. RESULTS: In contrast to findings in the healthy controls, cognitive functions in the depressed patients correlated significantly with rCBF in specified regions of interest in only a few instances. CONCLUSION: Our study indicates that disturbed cognitive functions in depression do not relate to specific areas of the brain in the same way as normal cognitive functioning, suggesting that the abnormalities of brain function in major depression may be qualitative, rather than quantitative, in nature.

AB - OBJECTIVE: To clarify the relationship between cognitive functions and regional cerebral blood flow (rCBF) in a large group of depressed patients compared with healthy controls. METHOD: A set of principal components was extracted from scores of a battery of neuropsychological tests of 40 patients suffering from major depression and 49 healthy controls. The components were correlated by multiple linear regression analyses to selected regions of interest in the brain obtained from positron emission tomography images. RESULTS: In contrast to findings in the healthy controls, cognitive functions in the depressed patients correlated significantly with rCBF in specified regions of interest in only a few instances. CONCLUSION: Our study indicates that disturbed cognitive functions in depression do not relate to specific areas of the brain in the same way as normal cognitive functioning, suggesting that the abnormalities of brain function in major depression may be qualitative, rather than quantitative, in nature.

M3 - Journal article

C2 - 12807375

VL - 108

SP - 32

EP - 40

JO - Acta Psychiatrica Scandinavica

JF - Acta Psychiatrica Scandinavica

SN - 0001-690X

IS - 1

ER -