Abstract
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Thoracic Oncology |
| Vol/bind | 4 |
| Udgave nummer | 5 |
| Sider (fra-til) | 608-14 |
| Antal sider | 7 |
| ISSN | 1556-0864 |
| DOI | |
| Status | Udgivet - 2009 |
Bibliografisk note
Keywords: Adenocarcinoma; Adult; Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Denmark; Early Detection of Cancer; Epidemiologic Research Design; False Positive Reactions; Female; Humans; Lung Neoplasms; Male; Mass Screening; Middle Aged; Neoplasm Staging; Prevalence; Prognosis; Sensitivity and Specificity; Smoking; Tomography, X-Ray ComputedAdgang til dokumentet
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I: Journal of Thoracic Oncology, Bind 4, Nr. 5, 2009, s. 608-14.
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review
}
TY - JOUR
T1 - The Danish randomized lung cancer CT screening trial
T2 - overall design and results of the prevalence round
AU - Pedersen, Jesper H
AU - Ashraf, Haseem
AU - Dirksen, Asger
AU - Bach, Karen
AU - Hansen, Hanne
AU - Toennesen, Phillip
AU - Thorsen, Hanne
AU - Brodersen, John
AU - Skov, Birgit Guldhammer
AU - Døssing, Martin
AU - Mortensen, Jann
AU - Richter, Klaus
AU - Clementsen, Paul
AU - Seersholm, Niels
N1 - Keywords: Adenocarcinoma; Adult; Aged; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Denmark; Early Detection of Cancer; Epidemiologic Research Design; False Positive Reactions; Female; Humans; Lung Neoplasms; Male; Mass Screening; Middle Aged; Neoplasm Staging; Prevalence; Prognosis; Sensitivity and Specificity; Smoking; Tomography, X-Ray Computed
PY - 2009
Y1 - 2009
N2 - INTRODUCTION: Lung cancer screening with low dose computed tomography (CT) has not yet been evaluated in randomized clinical trials, although several are underway. METHODS: In The Danish Lung Cancer Screening Trial, 4104 smokers and previous smokers from 2004 to 2006 were randomized to either screening with annual low dose CT scans for 5 years or no screening. A history of cigarette smoking of at least 20 pack years was required. All participants have annual lung function tests, and questionnaires regarding health status, psychosocial consequences of screening, smoking habits, and smoking cessation. Baseline CT scans were performed in 2052 participants. Pulmonary nodules were classified according to size and morphology: (1) Nodules smaller than 5 mm and calcified (benign) nodules were tabulated, (2) Noncalcified nodules between 5 and 15 mm were rescanned after 3 months. If the nodule increased in size or was larger than 15 mm the participant was referred for diagnostic workup. RESULTS: At baseline 179 persons showed noncalcified nodules larger than 5 mm, and most were rescanned after 3 months: The rate of false-positive diagnoses was 7.9%, and 17 individuals (0.8%) turned out to have lung cancer. Ten of these had stage I disease. Eleven of 17 lung cancers at baseline were treated surgically, eight of these by video assisted thoracic surgery resection. CONCLUSIONS: Screening may facilitate minimal invasive treatment and can be performed with a relatively low rate of false-positive screen results compared with previous studies on lung cancer screening.
AB - INTRODUCTION: Lung cancer screening with low dose computed tomography (CT) has not yet been evaluated in randomized clinical trials, although several are underway. METHODS: In The Danish Lung Cancer Screening Trial, 4104 smokers and previous smokers from 2004 to 2006 were randomized to either screening with annual low dose CT scans for 5 years or no screening. A history of cigarette smoking of at least 20 pack years was required. All participants have annual lung function tests, and questionnaires regarding health status, psychosocial consequences of screening, smoking habits, and smoking cessation. Baseline CT scans were performed in 2052 participants. Pulmonary nodules were classified according to size and morphology: (1) Nodules smaller than 5 mm and calcified (benign) nodules were tabulated, (2) Noncalcified nodules between 5 and 15 mm were rescanned after 3 months. If the nodule increased in size or was larger than 15 mm the participant was referred for diagnostic workup. RESULTS: At baseline 179 persons showed noncalcified nodules larger than 5 mm, and most were rescanned after 3 months: The rate of false-positive diagnoses was 7.9%, and 17 individuals (0.8%) turned out to have lung cancer. Ten of these had stage I disease. Eleven of 17 lung cancers at baseline were treated surgically, eight of these by video assisted thoracic surgery resection. CONCLUSIONS: Screening may facilitate minimal invasive treatment and can be performed with a relatively low rate of false-positive screen results compared with previous studies on lung cancer screening.
U2 - 10.1097/JTO.0b013e3181a0d98f
DO - 10.1097/JTO.0b013e3181a0d98f
M3 - Journal article
C2 - 19357536
SN - 1556-0864
VL - 4
SP - 608
EP - 614
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 5
ER -