The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas

Zarah Glad Zimling; Anne Jørgensen; Eric Santoni-Rugiu

doi:10.1111/j.1365-2559.2012.04196.x

The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas

Zarah Glad Zimling, Anne Jørgensen, Eric Santoni-Rugiu

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

24 Citationer (Scopus)

Abstract

Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.

Originalsprog	Engelsk
Tidsskrift	Histopathology
Vol/bind	60
Udgave nummer	6B
Sider (fra-til)	E96-105
ISSN	0309-0167
DOI	https://doi.org/10.1111/j.1365-2559.2012.04196.x
Status	Udgivet - 2012

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title = "The diagnostic value of immunohistochemically detected methylthioadenosine phosphorylase deficiency in malignant pleural mesotheliomas",

abstract = " Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.",

author = "Zimling, {Zarah Glad} and Anne J{\o}rgensen and Eric Santoni-Rugiu",

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AB - Malignant pleural mesothelioma (MPM) often causes diagnostic difficulties for pathologists. We assessed whether loss of methylthioadenosine phosphorylase (MTAP), a key enzyme in the intracellular recycling of adenosine triphosphate (ATP) often deleted in MPM, could be detected with immunohistochemistry (IHC) and used as a diagnostic marker for MPM.

U2 - 10.1111/j.1365-2559.2012.04196.x

DO - 10.1111/j.1365-2559.2012.04196.x

M3 - Journal article

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