TY - JOUR
T1 - The effect of coarse wheat bran in the irritable bowel syndrome lA double-blind cross-over study
AU - Arffmann, S
AU - Andersen, Jens Rikardt
AU - Hegnhøj, J
AU - Schaffalitzky De Muckadell, O B
AU - Mogensen, N B
AU - Krag, Einar
N1 - (Ekstern)
PY - 1985
Y1 - 1985
N2 - Dietary supplementation with wheat bran has been widely advocated as a first-line treatment of patients with the irritable bowel syndrome (IBS). Few controlled trials have been reported, and the results are, furthermore, contradictory. The present study comprised 20 patients with IBS, of whom 18 (14 women, 4 men) completed the trial. The two treatment periods of 6 weeks each, with a daily intake of 30 g coarse wheat bran or 30 g placebo bran, respectively, were randomized in a double-blind cross-over design. Wheat bran significantly (P < 0.05) increased the stool weight and shortened the intestinal transit time but was without significant effect on symptoms like abdominal pain, distension, and rumbling. No significant effect on the colonic motility index was shown. We conclude that coarse wheat bran used as the only treatment in IBS does not provide a sufficient effect in a 6-week period. However, wheat bran seems to be justified in the treatment of constipation.
AB - Dietary supplementation with wheat bran has been widely advocated as a first-line treatment of patients with the irritable bowel syndrome (IBS). Few controlled trials have been reported, and the results are, furthermore, contradictory. The present study comprised 20 patients with IBS, of whom 18 (14 women, 4 men) completed the trial. The two treatment periods of 6 weeks each, with a daily intake of 30 g coarse wheat bran or 30 g placebo bran, respectively, were randomized in a double-blind cross-over design. Wheat bran significantly (P < 0.05) increased the stool weight and shortened the intestinal transit time but was without significant effect on symptoms like abdominal pain, distension, and rumbling. No significant effect on the colonic motility index was shown. We conclude that coarse wheat bran used as the only treatment in IBS does not provide a sufficient effect in a 6-week period. However, wheat bran seems to be justified in the treatment of constipation.
KW - Colonic diseases
KW - Dietary fibre
KW - Functional
UR - http://www.scopus.com/inward/record.url?scp=0021912419&partnerID=8YFLogxK
U2 - 10.3109/00365528509091653
DO - 10.3109/00365528509091653
M3 - Journal article
C2 - 2988107
AN - SCOPUS:0021912419
VL - 20
SP - 295
EP - 298
JO - Scandinavian Journal of Gastroenterology. Supplement
JF - Scandinavian Journal of Gastroenterology. Supplement
SN - 0085-5928
IS - 3
ER -