TY - JOUR
T1 - The effect of flexible cognitive-behavioural therapy and medical treatment, including antidepressants on post-traumatic stress disorder and depression in traumatised refugees
T2 - pragmatic randomised controlled clinical trial
AU - Buhmann, Caecilie Böck
AU - Nordentoft, Merete
AU - Ekstrøm, Morten
AU - Lohmann, Jessica Mariana Carlsson
AU - Mortensen, Erik Lykke
N1 - © The Royal College of Psychiatrists 2016.
PY - 2016/3
Y1 - 2016/3
N2 - BACKGROUND: Little evidence exists on the treatment of traumatised refugees.AIMS: To estimate treatment effects of flexible cognitive-behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.METHOD: Randomised controlled clinical trial with 2 × 2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.RESULTS: A total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.CONCLUSIONS: In a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.
AB - BACKGROUND: Little evidence exists on the treatment of traumatised refugees.AIMS: To estimate treatment effects of flexible cognitive-behavioural therapy (CBT) and antidepressants (sertraline and mianserin) in traumatised refugees.METHOD: Randomised controlled clinical trial with 2 × 2 factorial design (registered with Clinicaltrials.gov, NCT00917397, EUDRACT no. 2008-006714-15). Participants were refugees with war-related traumatic experiences, post-traumatic stress disorder (PTSD) and without psychotic disorder. Treatment was weekly sessions with a physician and/or psychologist over 6 months.RESULTS: A total of 217 of 280 patients completed treatment (78%). There was no effect on PTSD symptoms, no effect of psychotherapy and no interaction between psychotherapy and medicine. A small but significant effect of treatment with antidepressants was found on depression.CONCLUSIONS: In a pragmatic clinical setting, there was no effect of flexible CBT and antidepressants on PTSD, and there was a small-to-moderate effect of antidepressants and psychoeducation on depression in traumatised refugees.
KW - Journal Article
KW - Research Support, Non-U.S. Gov't
U2 - 10.1192/bjp.bp.114.150961
DO - 10.1192/bjp.bp.114.150961
M3 - Journal article
C2 - 26541687
VL - 208
SP - 252
EP - 259
JO - The Journal of mental science
JF - The Journal of mental science
SN - 0960-5371
IS - 3
ER -